The Relationship between Obstructive Sleep Apnea and Atrial Fibrillation: A Complex Interplay.
The Relationship between Obstructive Sleep Apnea and Atrial Fibrillation: A Complex Interplay.
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DOI：
10.1155/2013/621736
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发表时间：
2013
影响因子：
4.3
通讯作者：
Garlitski AC
中科院分区：
文献类型：
--
作者：
Latina JM;Estes NA 3rd;Garlitski AC
近年来，越来越多的证据表明，阻塞性睡眠呼吸暂停(OSA)和房颤(AF)之间存在关联。OSA是一种常见的睡眠呼吸障碍，随着肥胖症的流行，OSA的患病率正在上升。房颤(AF)是最常见的心律失常。房颤是一个代价高昂的公共卫生问题，增加了患者中风、心力衰竭和全因死亡的风险。目前尚不清楚这种联系是基于共同的风险因素，如肥胖和高血压，还是OSA是一个独立的风险因素和本质上的致病因素。本文探讨了OSA易患房颤的病理生理学机制，卒中风险的临床意义，以及持续气道正压和房颤消融等有针对性的治疗策略。
In recent years, growing evidence suggests an association between obstructive sleep apnea (OSA), a common sleep breathing disorder which is increasing in prevalence as the obesity epidemic surges, and atrial fibrillation (AF), the most common cardiac arrhythmia. AF is a costly public health problem increasing a patient's risk of stroke, heart failure, and all-cause mortality. It remains unclear whether the association is based on mutual risk factors, such as obesity and hypertension, or whether OSA is an independent risk factor and causative in nature. This paper explores the pathophysiology of OSA which may predispose to AF, clinical implications of stroke risk in this cohort who display overlapping disease processes, and targeted treatment strategies such as continuous positive airway pressure and AF ablation.
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