The Benefits of Targeted Memory Reactivation for Consolidation in Sleep are Contingent on Memory Accuracy and Direct Cue-Memory Associations
The Benefits of Targeted Memory Reactivation for Consolidation in Sleep are Contingent on Memory Accuracy and Direct Cue-Memory Associations
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DOI：
10.5665/sleep.5772
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发表时间：
2016-05-01
期刊：
影响因子：
5.6
通讯作者：
Gaskell, M. Gareth
中科院分区：
文献类型：
--
作者：
Cairney, Scott A.;Lindsay, Shane;Gaskell, M. Gareth
研究目的：调查睡眠前的记忆准确性以及是否存在直接提示记忆关联如何影响目标记忆重新激活 (TMR) 的效果。方法：30 名参与者将 50 张图片中的每张与一个不相关的单词相关联，然后在两个单独的任务中将其与屏幕位置相关联。在图片定位训练期间，每张图片还呈现出语义相关的声音。因此，声音与图片位置直接相关，但与单词间接相关。在随后的小睡期间，一半的声音在慢波睡眠（SWS）中重播。然后检查 TMR 对图片位置记忆（直接线索记忆关联）和图片-单词对（间接线索记忆关联）的影响。结果：TMR 减少了回忆图片位置的整体记忆衰退。进一步的分析表明，TMR 对于睡前回忆起的低准确度图片位置有好处，但对那些高准确度回忆起来的图片位置却没有好处。 TMR 对于低准确度记忆的好处是通过在 SWS 中花费的时间来预测的。无论睡前的记忆准确性如何，TMR 对图片-单词对的记忆都没有好处。结论：TMR 对睡前低准确度的记忆回忆提供了最大的好处。 TMR 的记忆益处也可能取决于直接的提示记忆关联。
Study Objectives: To investigate how the effects of targeted memory reactivation (TMR) are influenced by memory accuracy prior to sleep and the presence or absence of direct cue-memory associations.Methods: 30 participants associated each of 50 pictures with an unrelated word and then with a screen location in two separate tasks. During picture-location training, each picture was also presented with a semantically related sound. The sounds were therefore directly associated with the picture locations but indirectly associated with the words. During a subsequent nap, half of the sounds were replayed in slow wave sleep (SWS). The effect of TMR on memory for the picture locations (direct cue-memory associations) and picture-word pairs (indirect cue-memory associations) was then examined.Results: TMR reduced overall memory decay for recall of picture locations. Further analyses revealed a benefit of TMR for picture locations recalled with a low degree of accuracy prior to sleep, but not those recalled with a high degree of accuracy. The benefit of TMR for low accuracy memories was predicted by time spent in SWS. There was no benefit of TMR for memory of the picture-word pairs, irrespective of memory accuracy prior to sleep.Conclusions: TMR provides the greatest benefit to memories recalled with a low degree of accuracy prior to sleep. The memory benefits of TMR may also be contingent on direct cue-memory associations.