CYSTIC-FIBROSIS HETEROZYGOTE RESISTANCE TO CHOLERA-TOXIN IN THE CYSTIC-FIBROSIS MOUSE MODEL
CYSTIC-FIBROSIS HETEROZYGOTE RESISTANCE TO CHOLERA-TOXIN IN THE CYSTIC-FIBROSIS MOUSE MODEL
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DOI：
10.1126/science.7524148
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发表时间：
1994-10-07
期刊：
影响因子：
56.9
通讯作者：
STUTTS, MJ
中科院分区：
文献类型：
--
作者：
GABRIEL, SE;BRIGMAN, KN;STUTTS, MJ
在囊性纤维化小鼠模型上，研究了囊性纤维化等位基因数目对霍乱毒素(CT)诱导的肠道分泌的影响。不表达CF跨膜电导调节蛋白(CFTR)的CF小鼠对CT的反应不分泌液体。杂合子在肠道上皮细胞中表达50%正常量的CFTR蛋白，并分泌50%的正常液体和氯离子。Cftr蛋白与CT诱导的氯离子和液体分泌的相关性提示，cf杂合子可能具有抵抗霍乱的选择性优势。
The effect of the number of cystic fibrosis (CF) alleles on cholera toxin (CT)-induced intestinal secretion was examined in the CF mouse model. CF mice that expressed no CF transmembrane conductance regulator (CFTR) protein did not secrete fluid in response to CT. Heterozygotes expressed 50 percent of the normal amount of CFTR protein in the intestinal epithelium and secreted 50 percent of the normal fluid and chloride ion in response to CT. This correlation between CFTR protein and CT-induced chloride ion and fluid secretion suggests that CF heterozygotes might possess a selective advantage of resistance to cholera.