The evolutionary dynamics of evolvability in a gene network model
The evolutionary dynamics of evolvability in a gene network model
复制标题
DOI：
10.1111/j.1420-9101.2008.01663.x
复制
发表时间：
2009-03-01
影响因子：
2.1
通讯作者：
Wagner, G. P.
中科院分区：
文献类型：
--
作者：
Draghi, J.;Wagner, G. P.
进化性，即种群的适应能力，最近已成为生物学中的一个主要统一概念。尽管进化性研究为许多重要的生物学问题提供了新的见解，但进化性的概念基础及其进化机制仍然存在争议。我们使用基因网络动力学模型的模拟进化来测试有争议的假设，即自然选择有利于高进化性，特别是在有性群体中。我们的结果最终证明，波动的自然选择可以提高模型基因网络适应新环境的能力。对这些网络进化动力学的详细研究为这一结果建立了广泛的有效性，并量化了导致进化性变化的进化力量。对这些网络的基因型-表型图的分析还揭示了连接进化性、遗传结构和鲁棒性的机制。我们的结果表明，进化性的进化可以对生物体的许多方面产生普遍影响。
Evolvability, the ability of populations to adapt, has recently emerged as a major unifying concept in biology. Although the study of evolvability offers new insights into many important biological questions, the conceptual bases of evolvability, and the mechanisms of its evolution, remain controversial. We used simulated evolution of a model of gene network dynamics to test the contentious hypothesis that natural selection can favour high evolvability, in particular in sexual populations. Our results conclusively demonstrate that fluctuating natural selection can increase the capacity of model gene networks to adapt to new environments. Detailed studies of the evolutionary dynamics of these networks establish a broad range of validity for this result and quantify the evolutionary forces responsible for changes in evolvability. Analysis of the genotype-phenotype map of these networks also reveals mechanisms connecting evolvability, genetic architecture and robustness. Our results suggest that the evolution of evolvability can have a pervasive influence on many aspects of organisms.