Agricultural chemical use and congenital cleft lip and/or palate.
Agricultural chemical use and congenital cleft lip and/or palate.
复制标题
农业化学品的使用和先天性唇裂和/或腭裂。
DOI：
10.1080/00039896.1981.10667627
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Shy,CM
中科院分区：
文献类型：
--
作者：
Gordon,JE;Shy,CM
在爱荷华州和密歇根州进行了一项病例对照研究，利用生命记录和生态、替代暴露措施。该研究假设预期，在农业化学品使用高峰期（4月至11月）与妊娠前三个月重合的胎儿中，暴露于农药的胎儿有过度的裂缝风险。为了检验这一假设，使用多元回归技术来帮助识别潜在的混杂因素;使用两种化学品暴露指数进行额外的分析，对潜在的混杂因素进行分层。这些分析的主要结果表明：（1）农业化学品效应（使用多重暴露指数）控制受孕季节;（2）受孕季节没有独立效应（因此零假设没有被拒绝）;（3）化学品/季节相互作用很小。这些结果意味着，如果暴露于农业化学品，事实上，裂缝的风险因素，一个扩展的模型，占多种农药的暴露可能比考虑暴露的季节更敏感，因为最初的假设。
A case-control study utilizing vital records and ecologic, surrogate exposure measures was conducted in Iowa and Michigan. The study hypothesis anticipated an excess risk of clefts among fetuses exposed during the peak agricultural chemical use period (April through Novembers) coincident with their first trimester of gestation. To examine this hypothesis, multiple regression techniques were used to aid identification of potential confounders; additional analyses, stratified on the potential confounders, were performed using two chemical exposure indices. The major findings of these analyses suggest: (1) an agricultural chemical effect (using the multiple exposure index) controlling for season of conception; (2) no independent effect of season of conception (thus the null hypothesis is not rejected); and (3) little chemical/season interaction. These results imply that if exposures to agricultural chemicals are, in fact, risk factors for clefts, an expanded model that accounts for multiple pesticidal exposures may be more sensitive than consideration of season of exposure, as originally hypothesized.