Influence of Japanese diet consumption during pregnancy and lactation on lipid metabolism in offspring
Influence of Japanese diet consumption during pregnancy and lactation on lipid metabolism in offspring
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DOI：
10.1016/j.nut.2018.06.006
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发表时间：
2019-02-01
期刊：
影响因子：
4.4
通讯作者：
Tsuduki, Tsuyoshi
中科院分区：
文献类型：
--
作者：
Ishikawa, Haruna;Guo, Xiaoxu;Tsuduki, Tsuyoshi
目的：以前的研究表明，肥胖在食用日本饮食的人中很少见，因为与美国饮食相比，日本饮食的卡路里含量较低。与此同时，据报道，在怀孕和哺乳期间限制母亲的热量摄入会产生减肥效果，增加了出生体重不足婴儿的可能性，从而增加了以后患肥胖症和糖尿病的风险。本研究的目的是检查母亲在怀孕和哺乳期间食用日本饮食对后代在以后的生活中患肥胖症和糖尿病的风险的影响。方法：将怀孕的小鼠分为三组，分别饲喂对照饮食、西方饮食和日本饮食，并将其后代抚养至7周龄。对18日龄和7周龄后代的检查显示，在怀孕和哺乳期间持续食用日本饮食对18日龄后代的健康状况没有影响，但7周龄后代的内脏脂肪和肝脏三酰甘油水平下降。此外，在怀孕和哺乳期间食用日本饮食的母亲的7周龄后代显示胰岛素抵抗的稳态模型评估降低，患糖尿病的风险降低。这种趋势也证实了在18日龄的后代。评价的机制表明，在后代的肝脏中的脂肪酸的合成被抑制的母亲的消费的日本diet.Conclusion：从这些结果，母亲消费的日本饮食在怀孕和哺乳期间没有不利影响的后代，和这种饮食的持续摄入量降低了风险，在后代以后的生活中发展肥胖症和糖尿病。(C)2018爱思唯尔公司All rights reserved.
Objective: Previous studies have demonstrated that obesity is rare among those who consume the Japanese diet because of its lower caloric content compared with the American diet. Meanwhile, it has been reported that maternal caloric restriction, which induces antiobesity effects, during pregnancy and lactation increases the likelihood of a low birthweight infant, which increases the risks for obesity and diabetes later in life. The aim of this study was to examine the influence of maternal consumption of the Japanese diet during pregnancy and lactation on the risk for obesity and diabetes in the offspring later in life.Methods: Pregnant mice were divided into three groups and fed either a control diet, Western diet, or Japanese diet, and their offspring were raised until 7 wk old.Results: Examinations of 18-d-old and 7-wk-old offspring showed no effect of consistently eating a Japanese diet during pregnancy and lactation on the health conditions of 18-d-old offspring, but 7-wk-old offspring showed a decrease in visceral fat and liver triacylglycerol levels. In addition, 7-wk-old offspring from mothers who consumed the Japanese diet during pregnancy and lactation showed a decrease in the homeostatic model assessment of insulin resistance and a reduced risk for developing diabetes. This tendency was also confirmed in 18-d-old offspring. Evaluation of the mechanism revealed that fatty acid synthesis in the liver of the offspring was suppressed by the mother's consumption of the Japanese diet.Conclusion: From these results, maternal consumption of the Japanese diet during pregnancy and lactation did not adversely affect the offspring, and continual intake of this diet reduced the risk for developing obesity and diabetes in the offspring later in life. (C) 2018 Elsevier Inc. All rights reserved.