CARCINOMA OF THE LUNG WITH INAPPROPRIATE ANTIDIURESIS. DEMONSTRATION OF ANTIDIURETIC-HORMONE-LIKE ACTIVITY IN TUMOR EXTRACT.
CARCINOMA OF THE LUNG WITH INAPPROPRIATE ANTIDIURESIS. DEMONSTRATION OF ANTIDIURETIC-HORMONE-LIKE ACTIVITY IN TUMOR EXTRACT.
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不适当的抗利尿剂引起的肺癌。
DOI：
10.1056/nejm196309122691102
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发表时间：
1963
期刊：
影响因子：
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通讯作者：
W. H. Sawyer
中科院分区：
文献类型：
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作者：
T. Amatruda;P. Mulrow;J. Gallagher;W. H. Sawyer
肺癌与低钠血症和肾性钠丢失的相关性已有多篇报道。Schwartz等1首次证实了该综合征患者存在不适当的抗利尿作用，并认为这是由于抗利尿激素分泌不当所致。目前还没有这类患者血液中加压素水平升高的报道。然而，即使在最大程度的抗利尿作用下，外周血中加压素的浓度也很容易通过目前可用的提取和生物测定方法逃脱检测。该综合征的发病机制尚不清楚，但其神经基础是由于神经系统的参与。
THE association of carcinoma of the lung with hyponatremiaand renal sodium loss has been reported on several occasions. Schwartz et al.1 first demonstrated the presence of inappropriate antidiuresis in patients with this syndrome and suggested that it was due to inappropriate secretion of antidiuretic hormone. There have been no reports of elevated levels of vasopressin in the blood of such patients. Even in maximal antidiuresis, however, peripheral blood concentrations of vasopressin could easily escape detection by presently available methods for extraction and biologic assay. The pathogenesis of the syndrome has been obscure, but a neurogenic basis due to involvement of . . .