Relationship between serum 25-hydroxyvitamin D and pulmonary function in the Third National Health and Nutrition Examination Survey
Relationship between serum 25-hydroxyvitamin D and pulmonary function in the Third National Health and Nutrition Examination Survey
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DOI：
10.1378/chest.128.6.3792
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发表时间：
2005-12-01
期刊：
影响因子：
9.6
通讯作者：
Scragg, R
中科院分区：
文献类型：
--
作者：
Black, PN;Scragg, R
背景：年龄、性别、身高、种族和吸烟是肺功能的重要决定因素，但不能解释个体之间的所有差异。低浓度的维生素D与许多疾病有关，包括骨质疏松症、高血压和I型糖尿病。目的：确定25-羟基维生素D血清浓度与肺功能的关系。设计、地点与对象：本研究采用1988年至1994年美国第三次国民健康与营养检查调查的数据进行分析。结果：在调整了年龄、性别、身高、体重指数、种族和吸烟史后，平均FEV1为126毫升(SE，22毫升)，与血清25-羟基维生素D水平最低的五分之一(>；=85.7nmol/L)相比，平均FVC增加172毫升(SE，26毫升)。
Context: Age, gender, height, ethnicity, and smoking are important determinants of lung function but do not explain all of the variation between individuals. Low concentrations of vitamin D have been associated with a number of diseases, including osteoporosis, hypertension, and type I diabetes. It is possible that serum concentrations of vitamin D might also influence pulmonary function.Ojectives: To determine the relationship between serum concentrations of 25-hydroxy vitamin D and pulmonary function.Design, setting and participants: The analysis was conducted using data from the Third National Health and Nutrition Examination Survey, which was a cross-sectional survey of the US civilian population that was conducted from 1988 to 1994. The analyses were restricted to 14,091 people who >= 20 years of age, were interviewed at mobile examination centers, and had undergone spirometry, and in whom serum 25-hydroxy vitamin D levels had been measured.Results: After adjustment for age, gender, height, body mass index, ethnicity, and smoking history, the mean FEV1 was 126 mL (SE, 22 mL), and the mean FVC was 172 mL (SE, 26 mL) greater for the highest quintile of serum 25-hydroxy vitamin D level (>= 85.7 nmol/L) compared with the lowest quintile (