NK Cell Enhancement of Antigen Presentation by B Lymphocytes
NK Cell Enhancement of Antigen Presentation by B Lymphocytes
复制标题
DOI：
10.4049/jimmunol.0803220
复制
发表时间：
2009-03-01
影响因子：
4.4
通讯作者：
Yuan, Dorothy
中科院分区：
文献类型：
--
作者：
Jennings, Paula;Yuan, Dorothy
Ag呈递给CD 4 T细胞可以由许多细胞类型介导，这取决于Ag首次遇到的解剖部位。对于血源性抗原，原位定位于脾脏中的细胞应该是主要的参与者。现在有很多证据表明，B细胞抗原呈递在记忆T细胞的启动中可能特别重要。大多数NK细胞也位于脾脏。由于我们先前已经表明NK细胞可以调节B细胞分化的各个方面，我们考虑了NK细胞也可以影响B细胞的Ag呈递的可能性。通过在免疫前特异性耗竭NK细胞，我们在本文中表明NK细胞在调节B细胞加工并将Ag呈递给T细胞的能力中起重要作用。这些效应在记忆T细胞的产生中特别重要。体外实验进一步证实了这一发现，表明这种增强不需要IFN-γ，而是由直接的细胞-细胞相互作用介导的。这些结果首次表明，先天反应的一个组成部分的快速激活甚至可以对Ag特异性记忆反应产生影响。免疫学杂志，2009，182：2879-2887.
Ag presentation to CD4 T cells can be mediated by a number of cell types depending on the anatomical site in which Ag is first encountered. For blood borne Ags, cells localized in situ in the spleen should be major players. There is now much evidence that B cell Ag presentation may he particularly important in the priming of memory T cells. The majority of NK cells are also localized the spleen. Inasmuch as we have previously shown that NK cells can modulate various aspects of B cell differentiation, we entertained the possibility (lint NK cells can also influence Ag presentation by B cells. By specific depletion of NK cells before immunization, we show herein that NK cells play an important role in modulating the ability of B cells to process and present Ag to T cells. These effects are particularly important in the generation of memory T cells. The findings are further substantiated by in vitro experiments showing that the enhancement does not require IFN-gamma but is mediated by direct cell-cell interaction. These results show, for the first time, that the rapid activation of a component of the innate response can even exert effects on the Ag-specific memory response. The Journal of Immunology, 2009, 182: 2879-2887.