Early administration of YT-146, an adenosine A2 receptor agonist, inhibits neointimal thickening after rat femoral artery endothelium injury.
Early administration of YT-146, an adenosine A2 receptor agonist, inhibits neointimal thickening after rat femoral artery endothelium injury.
复制标题
早期给予 YT-146（一种腺苷 A2 受体激动剂）可抑制大鼠股动脉内皮损伤后的新生内膜增厚。
DOI：
10.1016/0014-2999(95)00334-h
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发表时间：
1995
影响因子：
5
通讯作者：
M. Nakashima
中科院分区：
文献类型：
--
作者：
Y. Takiguchi;Mitsuyo Nagano;Y. Ikeda;M. Nakashima
已知腺苷通过腺苷a2受体激活抑制体外血管平滑肌细胞增殖。我们测试了腺苷a2受体激动剂2-辛基腺苷（YT-146）对光化学诱导的大鼠股动脉内皮损伤后体内内膜增厚的抑制作用。YT-146 （1 mg/kg/天）在伤后3、7、28天连续给予。无论给药时间长短，YT-146均显著降低损伤后28天的内膜面积和内膜与内侧面积之比。这些结果表明，YT-146可能抑制新生内膜形成的早期事件。效果是持久的，即使在短期服用后停止使用YT-146也不会逆转。
Adenosine is known to inhibit vascular smooth muscle cell proliferation in vitro via adenosine A2receptor activation. We tested the inhibitory effect of an adenosine A2receptor agonist, 2-octynyladenosine (YT-146), on in vivo intimal thickening following a photochemically induced injury of the endothelium of rat femoral artery. YT-146 (1 mg/kg/day) was administered s.c. for the first 3, 7 or 28 days after the injury. YT-146 significantly decreased neointimal area and the ratio of intima to medial area measured 28 days after the injury, regardless of the duration of administration. These results suggest that YT-146 may inhibit the early events of neointimal formation. The effect is long lasting and is not reversed even if YT-146 is stopped after a short course of administration.