ACTIVITY OF BULBAR RESPIRATORY NEURONS DURING FICTIVE COUGHING AND SWALLOWING IN THE DECEREBRATE CAT
ACTIVITY OF BULBAR RESPIRATORY NEURONS DURING FICTIVE COUGHING AND SWALLOWING IN THE DECEREBRATE CAT
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DOI：
10.1113/jphysiol.1994.sp020361
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发表时间：
1994-10-15
影响因子：
5.5
通讯作者：
EZURE, K
中科院分区：
文献类型：
--
作者：
OKU, Y;TANAKA, I;EZURE, K
1.在去大脑、麻痹和人工通气猫上，研究了电刺激上级喉神经（SLN）诱发的虚拟咳嗽和吞咽过程中延髓呼吸神经元的行为。通过记录膈神经、舌下神经和腹神经的活动来监测虚构的咳嗽、吞咽和呼吸.腹侧呼吸组（VRG）和Botzinger复合体（BOT）的呼吸神经元进行细胞外记录。分析的神经元类型包括BOT区的吸气递减神经元（I-DEC）、呼气递增神经元（E-AUG）和呼气递减神经元（E-DEC），以及VRG区的吸气递增神经元（I-AUG）和呼气递增神经元（E-AUG）.在模拟咳嗽过程中，所有的吸气和呼气神经元分别在咳嗽的吸气和呼气相处于活跃状态。放电的I-DEC和I-AUG神经元的增加和延长与增强的吸气活动的膈神经。VRG的E-AUG神经元的活动与腹神经的活动不平行，提示存在额外的神经元参与虚构咳嗽时腹神经活动的产生.在虚构的吞咽，一半的I-DEC神经元发射短暂的舌下神经丛发作与吞咽;发射抑制在其余的舌下神经丛。其他I-DEC神经元在舌下神经爆发时仅仅沉默。一些I-AUG神经元在舌下神经爆发的前半部分被激活，而另一些则保持沉默。伴随吞咽的膈神经放电可能起源于I-AUG神经元的这种活动。（BOT和VRG）和大多数E-DEC BOT神经元在吞咽过程中受到抑制。5我们得出结论，BOT和VRG的这五种呼吸神经元参与了咳嗽和吞咽的时空组织活动的产生，并且用于呼吸的神经元网络的至少一部分被用于这些非呼吸活动的网络共享。
1. The behaviour of medullary respiratory neurons was studied during fictive coughing and swallowing evoked by electrical stimulation of the superior laryngeal nerve (SLN) in decerebrate, paralysed and artificially ventilated cats. Fictive coughing, swallowing and respiration were monitored by recording activities of the phrenic, hypoglossal and abdominal nerves.2. Extracellular recordings were made from respiratory neurons in the ventral respiratory group (VRG) and in the Botzinger complex (BOT). The neuronal types analysed included decrementing inspiratory neurons (I-DEC), augmenting expiratory neurons (E-AUG) and decrementing expiratory neurons (E-DEC) from the BOT area, and augmenting inspiratory neurons (I-AUG) and augmenting expiratory neurons (E-AUG) from the VRG area.3. During fictire coughing, all the inspiratory and expiratory neurons mere active during the inspiratory and expiratory phases of coughing, respectively. The firing of both I-DEC and I-AUG neurons was increased and prolonged in association with the augmented inspiratory activity of the phrenic nerve. The activity of E-AUG neurons of the VRG did not parallel the abdominal nerve activity, suggesting the existence of additional neurons which participate in the generation of abdominal nerve activity during fictive coughing.4. During fictive swallowing, half of I-DEC neurons fired transiently at the onset of hypoglossal bursts associated with swallowing; the firing was suppressed during the rest of the hypoglossal bursts. Other I-DEC neurons mere silent during hypoglossal bursts. Some I-AUG neurons fired during the initial half of hypoglossal bursts, and others were silent. The brief phrenic activitS accompanying the swallowing might have originated from this activity in I-AUG neurons, The discharges of all E-AUG neurons (BOT and VRG) and the majority of E-DEC BOT neurons were suppressed during swallowing.5 We conclude that these five types of respiratory neurons of the BOT and VRG are involved in the generation of the spatiotemporally organized activity of coughing and swallowing, and that at least a part of the neuronal network for respiration is shared by networks for these non-respiratory activities.