Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer
Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer
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DOI：
10.1021/acsnano.6b03148
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发表时间：
2016-08-01
期刊：
影响因子：
17.1
通讯作者：
Li, Yaping
中科院分区：
文献类型：
--
作者：
Cao, Haiqiang;Dan, Zhaoling;Li, Yaping
肿瘤转移导致乳腺癌的高死亡率，并且由于药物的递送效率差而难以治疗。在此，我们报告了用分离的巨噬细胞膜包裹载药脂质体，以改善向转移部位的递送。巨噬细胞膜装饰增加了转移性4T1乳腺癌细胞中emtansine脂质体的细胞摄取，并对细胞活力具有抑制作用。在体内，巨噬细胞膜使脂质体能够靶向转移细胞，对乳腺癌肺转移产生显著的抑制作用。我们的研究结果提供了一种通过巨噬细胞的生物学特性来增强纳米颗粒在体内治疗癌症转移的医疗性能的仿生策略。
Cancer metastasis leads to high mortality of breast cancer and is difficult to treat because of the poor delivery efficiency of drugs. Herein, we report the wrapping of a drug-carrying liposome with an isolated macrophage membrane to improve delivery to metastatic sites. The macrophage membrane decoration increased cellular uptake of the emtansine liposome in metastatic 4T1 breast cancer cells and had inhibitory effects on cell viability. In vivo, the macrophage membrane enabled the liposome to target metastatic cells and produced a notable inhibitory effect on lung metastasis of breast cancer. Our results provide a biomimetic strategy via the biological properties of macrophages to enhance the medical performance of a nanoparticle in vivo for treating cancer metastasis.