Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database
Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database
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DOI：
10.1016/j.numecd.2007.05.002
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发表时间：
2008-11-01
影响因子：
3.9
通讯作者：
Bonadonna, Riccardo C.
中科院分区：
文献类型：
--
作者：
Bonora, Enzo;Capaldo, Brunella;Bonadonna, Riccardo C.
背景和目标：我们评估是否高胰岛素血症和/或胰岛素抵抗是独立相关的血脂，尿酸和血压在non-diabetic subjects.Methods和结果：一个数据库的非糖尿病意大利受试者最近已经成立，使用高胰岛素正葡萄糖钳夹研究的数据进行了使用标准技术（40 mU每分钟每平方米的体表面积）。在此数据库中，我们评估了空腹血浆胰岛素（FPI）、钳夹期间代谢的葡萄糖（M）与非糖尿病受试者的血浆甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、尿酸（UA）水平以及血压（BP）的关系
Background and aims: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects.Methods and results: A database of non-diabetic Italian subjects has recently been set up using data from hyperinsulinemic euglycemic clamp studies carried out using the standard technique (40 mU per min per square meter of body surface area). In this database we evaluated the relationships between fasting plasma insulin (FPI), glucose metabolized during clamp (M) and plasma levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA) as well as blood pressure (BP) in non-diabetic subjects with fasting plasma glucose