The UCLA population studies of chronic obstructive respiratory disease. 5. Agreement and disagreement of tests in identifying abnormal lung function.
The UCLA population studies of chronic obstructive respiratory disease. 5. Agreement and disagreement of tests in identifying abnormal lung function.
复制标题
加州大学洛杉矶分校慢性阻塞性呼吸道疾病的人群研究。
作者：
R. Detels;D. Tashkin;M. Simmons;H. Carmichael;J. Sayre;S. Rokaw;A. Coulson
通过对洛杉矶1,201名居民的症状、肺功能测定、流量-容量（FV）曲线、单次呼吸氮试验（SBNT）和比气道传导率（SGaw）与FEV 1/FVC比值和其他试验进行交叉比较，评估这些试验的相对敏感性和特异性。肺量测定和流量-容积曲线被认为是最敏感的，但合理的具体的复合措施，和FEV 1/FVC和V75是最敏感的个人指标。在当前吸烟者中，FEV 1/FVC异常（23%）比FEF 25 -75%（16%）更常见，与FEF 25 -75%异常（88%）的一致性更高，并且当FEF 25 -75%正常时（9%）被确定为异常的个体比例高于反之亦然。SGaw和SBNT显示与FEV 1/FVC的一致性较差，并将更多的FEV 1/FVC正常的个体识别为异常。虽然目前吸烟者中有排痰性咳嗽的比例相对较高（26%），但没有一项功能测试显示与此症状合理一致。这些研究结果表明：1）肺量测定、流量-容积曲线、V75和FEV 1/FVC是呼吸损害的相对敏感和特异性指标; 2）肺量测定和FV曲线提供相似但不完全重叠的信息; 3）SGaw和SBNT产生与其他测试不同（或特异性较低）的信息;以及4）通过排痰性咳嗽识别的吸烟影响与通过其他测试识别的吸烟影响不同。
The relative sensitivity and specificity of symptoms, spirometry, the flow-volume (FV) curve, the single-breath nitrogen test (SBNT), and specific airway conductance (SGaw) were estimated by cross comparison of these tests with the FEV1/FVC ratio and other tests in 1,201 residents of Los Angeles. Spirometry and the flow-volume curve were estimated to be the most sensitive, yet reasonably specific composite measures, and FEV1/FVC and V75 to be the most sensitive individual indices. Among current smokers, FEV1/FVC was more frequently abnormal (23 percent) than FEF25-75% (16 percent), showed higher concordance with an abnormal FEF25-75% (88 percent), and identified a greater percentage of individuals as abnormal when the FEF25-75% was normal (9 percent) than vice versa. SGaw and SBNT showed a poor concordance with FEV1/FVC and identified more individuals as abnormal who had a normal FEV1/FVC. Although the proportion of current smokers with productive cough was relatively high (26 percent), none of the function tests showed a reasonable concordance with this symptom. These findings suggest that: 1) spirometry, the flow-volume curve, V75 and FEV1/FVC are relatively sensitive and specific indicators of respiratory impairment; 2) spirometry and the FV curve provide similar but not completely overlapping information; 3) SGaw and SBNT yield different (or less specific) information than the other tests; and 4) effects of cigarette smoking identified by productive cough are different from those identified by other tests.
小气道病理学与切除的人肺中 III 相的闭合能力增加和异常斜率有关。
DOI：
10.1164/arrd.1980.121.3.449
发表时间：
1980
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Petty,TL;Silvers,GW;Stanford,RE;Baird,MD;Mitchell,RS
通讯作者：
Mitchell,RS