Prognostic Value of E-Cadherin and β-Cagengn tin Triple-Negative Breast Cancer
Prognostic Value of E-Cadherin and β-Cagengn tin Triple-Negative Breast Cancer
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DOI：
10.1093/ajcp/aqw183
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发表时间：
2016-11-01
影响因子：
3.5
通讯作者：
Wei, Shi
中科院分区：
文献类型：
--
作者：
Shen, Tiansheng;Zhang, Kui;Wei, Shi
目的：分析三阴性乳腺癌（TNBC）中E-cadherin和β-catenin的表达情况，评估其预后意义。方法：半定量检测E-cadherin和β-catenin的表达，并与其他病理因素和生存结局相关。结果：在72例连续TNBC中，56%显示E-cadherin或β-catenin膜表达减少，且相互之间有很强的相关性。在分析的临床病理因素中，肿瘤大小和淋巴结状态与总生存率和疾病特异性生存率显着相关，而通过多变量分析，后者仍然是一个独立因素。通过单变量和多变量分析，E-cadherin和β-catenin的减少均与较差的总生存期和疾病特异性生存显着相关。结论：E-cadherin和β-catenin的表达提供了独立于常规病理因素的判别性预后能力，从而进一步强化了细胞粘附分子在肿瘤转移过程中的重要作用，特别是在TNBC中。
Objectives:To analyze the expression of E-cadherin and β-catenin in triple-negative breast cancer (TNBC) to assess their prognostic significance.Methods:The expression of E-cadherin and β-catenin was examined semiquantitatively and correlated with other pathologic factors and survival outcomes.Results:Of 72 consecutive TNBCs, 56% showed reduced membranous expression of E-cadherin or β-catenin, with a strong correlation to each other. Of the clinicopathologic factors analyzed, tumor size and nodal status were significantly associated with overall survival and disease-specific survival, while the latter remained an independent factor by multivariate analysis. Reduced E-cadherin and β-catenin were both significantly associated with a poor overall survival and disease-specific survival by univariate and multivariate analyses.Conclusions:E-cadherin and β-catenin expression provides discriminative prognostic power independent of conventional pathologic factors, thus further reinforcing the important role of cell adhesion molecules in the process of tumor metastasis, especially in TNBC.