Evaluation of a benzalkonium chloride hand sanitizer in reducing transient Staphylococcus aureus bacterial skin contamination in health care workers
Evaluation of a benzalkonium chloride hand sanitizer in reducing transient Staphylococcus aureus bacterial skin contamination in health care workers
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DOI：
10.1016/j.ajic.2019.08.030
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发表时间：
2020-05-01
影响因子：
4.9
通讯作者：
Fitzpatrick, Lisa
中科院分区：
文献类型：
--
作者：
Bondurant, Sidney;McKinney, Tanya;Fitzpatrick, Lisa
背景资料：本研究旨在评价一种新型市售洗手液的有效性，该洗手液使用0.12%苯扎氯铵（BZK）作为活性成分，与70%乙醇基洗手液相比，可减少医护人员（HCW）的金黄色葡萄球菌短暂皮肤污染。从40名HCW获得指尖触摸培养板，其中所有HCW根据疾病控制和预防中心的整个研究指南使用含有0.6%氯对二甲苯酚的抗菌皂洗手，同时根据疾病控制和预防中心的指导方针，在第一周继续使用70%乙醇洗手液。第一周后，测试对象使用BZK洗手液代替乙醇洗手液。结果：使用BZK和70%乙醇洗手液的一周内，医护人员指尖的金黄色葡萄球菌菌落总数显著低于使用70%乙醇洗手液的一周。结论：与70%乙醇洗手液使用周相比，BZK洗手液使用周HCW指尖上的瞬时金黄色葡萄球菌显著减少。(C)2019感染控制和流行病学专业人员协会，Inc.爱思唯尔公司出版
Background: This study was performed to evaluate the effectiveness of a new commercially available hand sanitizer using 0.12% benzalkonium chloride (BZK) as the active ingredient in reducing transient skin contamination with Staphylococcus aureus in health care workers (HCWs), as compared with the effectiveness of a 70% ethanol-based hand sanitizer.Methods: Fingertip touch culture plates were obtained from 40 HCWs in which all HCWs used antimicrobial soap containing 0.6% chloroxylenol for handwashing according to the Centers for Disease Control and Prevention guidelines for the entire study, while continuing to use the 70% ethanol-based hand sanitizer according to the Centers for Disease Control and Prevention guidelines for the first week. After the first week, the test subjects used the BZK hand sanitizer in place of the ethanol sanitizer. A paired sample t test was conducted to compare the mean bacterial colonies grown from HCWs fingertips during the use of the BZK and ethanol hand sanitizer.Results: The results showed a significant reduction in total bacterial colony counts of S aureus during the week of BZK use as compared with the week of 70% ethanol sanitizer use.Conclusions: There was a significant decrease in transient S aureus on the fingertips of HCWs in the BZK hand sanitizer use week as compared with the 70% ethanol hand sanitizer use week. (C) 2019 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc.