Influence of inhaled atropine on lung mucociliary function in humans.
Influence of inhaled atropine on lung mucociliary function in humans.
复制标题
吸入阿托品对人类肺粘膜纤毛功能的影响。
DOI：
10.1164/ajrccm/144.5.1042
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Foster,WM
中科院分区：
文献类型：
--
作者：
Groth,ML;Langenback,EG;Foster,WM
在不吸烟的健康受试者中研究了雾化硫酸阿托品对肺气道粘液清除的影响。通过口腔吸入并沉积在粘膜表面的放射性标记的不溶性颗粒来测量粘液转运；随后在 4 至 5 小时内通过无创、后部对齐的伽马相机对放射性标记的保留进行定量。安慰剂和阿托品清除测试在给定受试者中进行匹配，分别在气管支气管颗粒清除开始和结束时标记气溶胶的初始和最终（吸入后24小时）沉积模式。与安慰剂（0.9%氯化钠）相比，七名受试者在吸入 0.025 毫克/公斤体重的硫酸阿托品后，粘液纤毛功能出现延迟。根据活性与时间曲线下面积，阿托品的保留时间超过安慰剂时间 30% 以上 (p < 0.01)。吸入后阿托品 90 分钟时，max50 超出基线值 21%（p < 0.01）。阿托品治疗后，一名受试者出现尿潴留，所有受试者出现口干症。这些数据表明，局部递送至气道表面的单剂量硫酸阿托品延迟了健康受试者中气道粘液的连续流动，并且基础自主神经张力是最佳分泌和/或去除气管支气管分泌物的固有因素。
The influence of aerosolized atropine sulfate on lung airway mucus clearance was investigated in healthy human subjects who were nonsmokers. Mucus transport was measured with radiolabeled insoluble particles inhaled by mouth and deposited onto mucosal surfaces; subsequent retention of radiolabel was quantitated over a 4- to 5-h period by a noninvasive, posteriorly aligned, gamma camera. Placebo and atropine clearance tests were matched in a given subject for initial and for final (24-h postinhalation) deposition pattern of labeled aerosol at the onset and conclusion, respectively, of tracheobronchial particle clearance. In seven subjects mucociliary function was delayed after inhalation of 0.025 mg/kg body weight atropine sulfate as compared with placebo (0.9%NaCl). On the basis of the area under the activity versus time curves, retention times during atropine exceeded placebo times by more than 30%(p < 0.01). At 90 min postatropine inhalation, the max50exceeded baseline values by 21%(p < 0.01). Urine retention was present in one subject and xerostomia was present in all subjects after atropine. These data suggest that a single dose of atropine sulfate delivered topically to the airway surfaces delays the continuous flow of airway mucus in healthy subjects and that basal autonomic tone is an inherent factor for optimal secretion and/or removal of tracheobronchial secretions.