Nomenclature of monocytes and dendritic cells in blood
Nomenclature of monocytes and dendritic cells in blood
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DOI：
10.1182/blood-2010-02-258558
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发表时间：
2010-10-21
期刊：
影响因子：
20.3
通讯作者：
Lutz, Manfred B.
中科院分区：
文献类型：
--
作者：
Ziegler-Heitbrock, Loems;Ancuta, Petronela;Lutz, Manfred B.
单核细胞和树突状细胞谱系的细胞在血液中循环，并最终迁移到组织中，在那里它们进一步成熟并发挥各种功能，最显著的是免疫防御。近年来，这些细胞已被详细的特点与使用细胞表面标记和流式细胞术，亚群已被描述。本文提出了这些细胞的命名法，并定义了人和小鼠血液中3种类型的单核细胞（经典单核细胞、中间单核细胞和非经典单核细胞）和3种类型的树突细胞（浆细胞样树突细胞和2种骨髓树突细胞）。这一分类已得到国际免疫学会联合会命名委员会的批准，我们相信，这将促进专家之间和更广泛的科学界的交流。（Blood.2010;116（16）：e74-e80）
Monocytes and cells of the dendritic cell lineage circulate in blood and eventually migrate into tissue where they further mature and serve various functions, most notably in immune defense. Over recent years these cells have been characterized in detail with the use of cell surface markers and flow cytometry, and subpopulations have been described. The present document proposes a nomenclature for these cells and defines 3 types of monocytes (classical, intermediate, and nonclassical monocytes) and 3 types of dendritic cells (plasmacytoid and 2 types of myeloid dendritic cells) in human and in mouse blood. This classification has been approved by the Nomenclature Committee of the International Union of Immunological Societies, and we are convinced that it will facilitate communication among experts and in the wider scientific community. (Blood.2010;116(16):e74-e80)