The bronchoconstrictor properties of platelet-activating factor in humans.
The bronchoconstrictor properties of platelet-activating factor in humans.
复制标题
人类血小板激活因子的支气管收缩特性。
DOI：
10.1164/ajrccm/136.5.1145
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Patterson,R
中科院分区：
文献类型：
--
作者：
Rubin,AH;Smith,LJ;Patterson,R
血小板活化因子(PAF)是一种炎症介质，在实验动物的Iflfro和Ifllfo中引起支气管平滑肌收缩。为了研究PAF对人的呼吸道的影响，6名正常人和6名轻度哮喘受试者吸入PAF，吸入标准的支气管激发方案，雾化浓度从0.1到1000I1g/ml。雾化的PAF使6名正常人中的5名和6名哮喘患者中的3名产生了至少35%的比气道电导(SGAW)收缩。然而，在这些受试者中，在部分用力呼气动作(V30P)中测量到的肺活量30%的流量并没有减少至少30%，FEV也没有减少20%。8名PAF应答者对PAF的敏感性是乙酰甲胆碱的5~836倍。PAF无反应者的相对气道敏感性无法评估。正常受试者和哮喘受试者不能通过其对PAF的呼吸道反应来区分，也没有临床特征区分PAF反应者和无反应者。PAF的最大呼吸道反应发生在2~3min内，持续15~45min。没有晚期反应。
Platelet-activating factor (PAF) is an inflammatory mediator that causes bronchial smooth muscle contraction In Iflfro and In Ifllfo in experimental animals. To characterize the effect of PAF on human airways, 6 normal subjects and 6 SUbjectswith mild asthma inhaled PAFusing a standard bronchoprovocation protocol and nebulizer concentrations ranging from 0.1 to 1000I1g/ml. Aerosolized PAF produced bronchoconstrictlon In 5 of 6 normal and 3 of 6 asthmatic SUbjects as defined by at least a 35% decrease In specific airway conductance (SGaw). However, In these same subjects, flow rates measured at 30% of vital capacity from a partial forced expiratory maneuver (V30P) did not decrease at least 30% nor did the FEV, decrease by 20%. The 8 PAF responders were 5 to 836 times more sensitive to PAF than to methacholine when SGaw was used to assess the airway response. The relative airway sensitivity of the PAFnonresponders could not be assessed. Normal and asthmatic subjects could not be differentiated by their airway response to PAF, and there were no clinical features that differentiated PAF responders from nonresponders. The maximal airway response to PAFoccurred within 2 to 3 min and lasted 15to 45 min. There were no late reactions.