Smooth Muscle Proliferation in Chronically Injured Canine Pulmonary Arteries Is Reduced by a Potent Platelet Aggregation Inhibitor U-53,059
Smooth Muscle Proliferation in Chronically Injured Canine Pulmonary Arteries Is Reduced by a Potent Platelet Aggregation Inhibitor U-53,059
复制标题
强效血小板聚集抑制剂 U-53,059 可减少慢性损伤犬肺动脉中的平滑肌增殖
DOI：
10.1055/s-0038-1661313
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发表时间：
1985
影响因子：
6.7
通讯作者：
C. Rawlings
中科院分区：
文献类型：
--
作者：
R. Schaub;James Keith;C. Simmons;C. Rawlings
犬恶丝虫（DI）感染可造成犬肺动脉慢性损伤。这种损伤导致内皮细胞损失、血小板/白细胞粘附和平滑肌增殖。在本研究中，我们评估了环氧合酶抑制剂U-53，059对DI感染犬的血小板功能、血小板动力学、凝血和平滑肌增殖的影响。U-53，059显著抑制花生四烯酸/ ADP联合作用的血小板聚集。凝血和血液学参数不受DI感染或U-53，059治疗的影响。DI感染者血小板存活率和血小板致密颗粒数减少。病变的定量表明，与未给药犬相比，U-53，059降低了严重程度和密度。U-53，059是一种有效的血小板聚集抑制剂，可调节慢性血管损伤引起的平滑肌增殖。
Summary Dirofilaria immitis (DI) infection chronically injures canine pulmonary arteries. This injury produces endothelial cell loss, platelet/leukocyte adhesion, and smooth muscle proliferation. In the present study we assessed the effect of the cyclooxygenase inhibitor, U-53,059, on platelet function, platelet kinetics, coagulation, and smooth muscle proliferation in DI infected dogs. Platelet aggregation to the combination of arachidonic acid/ ADP was significantly inhibited by U-53,059. Coagulation and hematologic parameters were not effected by either DI infection or U-53,059 treatment. Platelet survival and the number of platelet dense granules were reduced in DI infection. Quantification of the lesions demonstrated that U-53,059 reduced both severity and density compared to non-treated dogs. U-53,059 is a potent and effective inhibitor of platelet aggregation which modifies smooth muscle proliferation produced by chronic vascular injury.