Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation.
Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation.
复制标题
Osterix转录因子在成骨细胞分化和骨形成中的研究进展
DOI：
10.3389/fcell.2020.601224
复制
发表时间：
2020
影响因子：
5.5
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Liu Q;Li M;Wang S;Xiao Z;Xiong Y;Wang G
随着人们寿命的延长，越来越多的患者因剧烈运动或其他骨相关疾病而发生骨折。成骨细胞介导的骨形成和破骨细胞介导的骨吸收之间的平衡是维持骨健康的基础。Osterix（Osx）是成骨细胞分化和骨矿化的重要转录因子。越来越多的证据表明，Osx不仅在膜内骨形成中起重要作用，而且通过参与终末软骨分化而影响软骨内成骨。由于Osx在骨骼发育和骨形成中的重要性，近年来Osx已成为一个新的研究热点。本文就Osx的功能及其对成骨细胞分化和骨量的调控研究进展作一综述。并对Osx在开发溶骨性疾病治疗新策略中的潜在作用进行了讨论。
With increasing life expectations, more and more patients suffer from fractures either induced by intensive sports or other bone-related diseases. The balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption is the basis for maintaining bone health. Osterix (Osx) has long been known to be an essential transcription factor for the osteoblast differentiation and bone mineralization. Emerging evidence suggests that Osx not only plays an important role in intramembranous bone formation, but also affects endochondral ossification by participating in the terminal cartilage differentiation. Given its essentiality in skeletal development and bone formation, Osx has become a new research hotspot in recent years. In this review, we focus on the progress of Osx’s function and its regulation in osteoblast differentiation and bone mass. And the potential role of Osx in developing new therapeutic strategies for osteolytic diseases was discussed.
登录
查看更多内容
影响因子：
3.5
作者：
Barbuto R;Mitchell J
通讯作者：
Mitchell J
影响因子：
4.1
作者：
Choi, You Hee;Han, Younho;Lee, Kwang Youl
通讯作者：
Lee, Kwang Youl
骨细胞连接蛋白 43 通道影响骨折愈合
影响因子：
5.6
作者：
Chen, Yunhe;Chen, Meng;Xu, Huiyun
通讯作者：
Xu, Huiyun
影响因子：
4
作者：
Gao, Yuan;Xiao, Fei;Chen, Xiaodong
通讯作者：
Chen, Xiaodong
影响因子：
6.2
作者：
Farr, Joshua N.;Rowsey, Jennifer L.;Khosla, Sundeep
通讯作者：
Khosla, Sundeep