Chronic repetitive transcranial magnetic stimulation (rTMS) on sleeping quality and mood status in drug dependent male inpatients during abstinence
Chronic repetitive transcranial magnetic stimulation (rTMS) on sleeping quality and mood status in drug dependent male inpatients during abstinence
复制标题
慢性重复经颅磁刺激（rTMS）对药物依赖男性住院患者戒断期间睡眠质量和情绪状态的影响
DOI：
10.1016/j.sleep.2019.01.052
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发表时间：
2019-06-01
期刊：
影响因子：
4.8
通讯作者：
Yuan, Ti-Fei
中科院分区：
文献类型：
--
作者：
Lin, Jian;Liu, Xiaoli;Yuan, Ti-Fei
背景：戒毒伴随着厌恶体验以及情绪状态的持久改变和睡眠质量的恶化。本研究调查了慢性重复经颅磁刺激（rTMS）对处于戒毒期的物质依赖住院患者的潜在影响。
方法：这是一项双盲研究，涉及105名依赖海洛因或甲基苯丙胺的男性住院患者（平均戒毒时间为6个月）。这些住院患者被随机分为10Hz干预组（n = 40）、假刺激组（n = 40）和对照组（等待名单，无治疗）（n = 25）。连续6周进行5次rTMS刺激，总计达到180,000次脉冲。对照组无干预措施。在干预6周前后，使用匹兹堡睡眠质量指数（PSQI）、焦虑自评量表（SAS）和抑郁自评量表（SDS）对患者进行评估。
结果：结果显示，6周的rTMS治疗显著改善了处于早期戒毒期的物质依赖住院患者的睡眠质量（p < 0.001），缓解了抑郁（p < 0.001）和焦虑状态（p < 0.001）。此外，活性TMS组与假刺激组和对照组之间存在显著差异。
结论：这些发现表明，慢性rTMS治疗对处于戒毒期的物质依赖住院患者具有积极影响。未来需要进一步研究以了解改善不同临床症状的潜在机制。（C）2019爱思唯尔有限公司。保留所有权利。
Background: Drug abstinence is accompanied by aversive experiences and lasting changes in mood status and worsening sleep quality. This study investigated the potential effects of chronic repetitive transcranial magnetic stimulation (rTMS) in substance dependent inpatients during abstinence.Methods: This was a double-blinded study with 105 males inpatients dependent on heroin or methamphetamine (average abstinence time was six months). The inpatients were randomly divided into 10 Hz intervention (n = 40), sham stimulation (n = 40) and control (waiting list, no treatment) (n = 25) groups. Five sessions of rTMS stimulation were administrated for six consecutive weeks, reaching a total of 180,000 pulses. There was no intervention for control group. Patients were assessed using the Pittsburgh Sleep Quality Index (PSQI), Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were assessed prior to and after six weeks of intervention.Results: The results showed that six weeks of rTMS treatment significantly improved the sleep quality (p < 0.001), alleviated depression (p < 0.001) and anxiety state (p < 0.001) of substance dependent inpatients in early abstinence. Furthermore, the active TMS group showed significant differences between sham and control groups.Conclusion: These findings suggested that chronic rTMS treatment have positive effects for substance dependent inpatients during abstinence. Future studies are required to understand the underlying mechanism for improving different clinical symptoms. (C) 2019 Elsevier B.V. All rights reserved.