Bone material strength index as measured by impact microindentation is low in patients with fractures irrespective of fracture site
Bone material strength index as measured by impact microindentation is low in patients with fractures irrespective of fracture site
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DOI：
10.1007/s00198-017-4054-8
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发表时间：
2017-08-01
影响因子：
4
通讯作者：
Appelman-Dijkstra, N. M.
中科院分区：
文献类型：
--
作者：
Malgo, F.;Hamdy, N. A. T.;Appelman-Dijkstra, N. M.
我们评估了骨材料强度指数（BMSi）与脆性骨折（包括椎体骨折）之间的关系。我们的数据表明，BMSi是低的，在所有骨折患者的低骨量，独立的患者是否持续的椎骨或非椎骨fraction.Introduction冲击微压痕（IMI）是一种新的技术，用于测量组织水平的性能在体内的皮质骨。以前的研究表明BMSi与非椎骨骨折之间存在关联，但与椎骨骨折的关联仍存在争议。本文的目的是评估BMSi和不同类型的脆性骨折，包括椎骨fracture.Methods之间的关系，在这个横断面研究中，我们测量BMSi在不同类型的脆性骨折和低骨量的男性和女性患者与IMI方法使用Osteoprobe（R）。脊椎骨折的诊断和分级的侧位脊柱radiographs.Results共132例患者被纳入本研究，其中101例（65名妇女）持续低能量骨折和31（平均年龄57.7 +/- 9.9岁）没有骨折的历史或放射学证据。在骨折患者中，53例（平均年龄62.8 ± 8.3岁）仅发生非椎骨骨折（VF-/Fx+），34例（平均年龄62.8 ± 9.9岁）发生椎骨和非椎骨骨折（VF+/Fx+），14例（平均年龄64.7 ± 9.3岁）仅发生椎骨骨折（VF+/Fx-）。经年龄和BMD调整后，所有三组骨折患者的BMSi值相似（分别为78.9 +/- 0.7、78.3 +/- 0.9和78.4 +/- 1.4; p = 0.866）。BMSi值与椎体骨折的数量和严重程度无关。结论低骨量骨折患者的BMSi值较低，无论是椎体骨折还是非椎体骨折。
We evaluated the relationship between bone material strength index (BMSi) and fragility fractures, including vertebral fractures. Our data showed that BMSi is low in all fracture patients with low bone mass, independently of whether patients sustained a vertebral or a non-vertebral fracture.Introduction Impact microindentation (IMI) is a new technique for the measurement of tissue level properties of cortical bone in vivo. Previous studies showed an association between BMSi and non-vertebral fractures, but an association with vertebral fractures is still being debated. The objective of this paper was to evaluate the relationship between BMSi and different types of fragility fractures, including vertebral fractures.Methods In this cross-sectional study, we measured BMSi in patients of both sexes with different types of fragility fractures and low bone mass with the IMI method using the Osteoprobe (R). Vertebral fractures were diagnosed and graded on lateral spine radiographs.Results A total of 132 patients were included in the study, of whom 101 patients (65 women) had sustained a low energy fracture and 31 (mean age 57.7 +/- 9.9 years) had no history or radiological evidence for a fracture. Of the fracture patients, 53 (mean age 62.8 +/- 8.3 years) had only non-vertebral fractures (VF-/Fx+), 34 (mean age 62.8 +/- 9.9 years) had vertebral and non-vertebral fractures (VF+/Fx+), and 14 (mean age 64.7 +/- 9.3 years) had only vertebral fractures (VF+/Fx-). BMSi values, adjusted for age and BMD, were similar for all three groups of fracture patients (78.9 +/- 0.7, 78.3 +/- 0.9, and 78.4 +/- 1.4, respectively; p = 0.866). BMSi valueswere not associated with number or severity of vertebral fractures.Conclusion Our data demonstrate that BMSi is low in fracture patients with low bone mass, irrespective of whether they sustained a vertebral fracture or a non-vertebral fracture.