In Vivo Imaging of Mineral Deposition in Carotid Plaque Using 18F-Sodium Fluoride PET/CT: Correlation with Atherogenic Risk Factors
In Vivo Imaging of Mineral Deposition in Carotid Plaque Using 18F-Sodium Fluoride PET/CT: Correlation with Atherogenic Risk Factors
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DOI：
10.2967/jnumed.110.081208
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发表时间：
2011-03-01
影响因子：
9.3
通讯作者：
Klutmann, Susanne
中科院分区：
文献类型：
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作者：
Derlin, Thorsten;Wisotzki, Christian;Klutmann, Susanne
本研究的目的是将无神经症状患者颈总动脉中 F-18-氟化钠的积累与心血管危险因素和颈动脉钙化斑块负荷相关联。方法：对 269 例肿瘤患者进行 F-18-氟化钠 PET/CT 检查。通过测量血池校正的标准化摄取值（目标与背景比）并将其与心血管危险因素和钙化斑块负荷进行比较，对颈总动脉中示踪剂的积累进行定性和半定量分析。结果：在 94 名 (34.9%) 患者的 141 个部位观察到 F-18-氟化钠的摄取。放射性示踪剂的积累与所有动脉粥样硬化病变中的钙化共定位。 F-18-氟化钠的摄取与年龄（P < 0.0001）、男性（P < 0.0001）、高血压（P < 0.002）和高胆固醇血症（P < 0.05）显着相关。钙化斑块的存在与这些危险因素显着相关，而且与糖尿病 (P < 0.0001)、吸烟史 (P = 0.03) 和既往心血管事件 (P < 0.01) 显着相关。 F-18-氟化钠摄取的存在与现有心血管危险因素的数量之间存在高度显着的相关性（r = 0.30，P < 0.0001）。结论：颈动脉 F-18-氟化钠摄取是颈动脉钙化斑块的替代指标，与心血管危险因素相关，并且在动脉粥样硬化血栓事件高危患者中更为常见，但与危险因素的相关性弱于钙化斑块负荷。这项研究为开展进一步的前瞻性研究提供了理论依据，以确定 F-18-氟化钠的摄取是否可以预测血管事件，或者是否可以用于监测药物治疗。
The purpose of this study was to correlate F-18-sodium fluoride accumulation in the common carotid arteries of neurologically asymptomatic patients with cardiovascular risk factors and carotid calcified plaque burden. Methods: Two hundred sixty-nine oncologic patients were examined by F-18-sodium fluoride PET/CT. Tracer accumulation in the common carotid arteries was analyzed both qualitatively and semiquantitatively by measuring the blood-pool-corrected standardized uptake value (target-to-background ratio) and comparing it with cardiovascular risk factors and calcified plaque burden. Results: F-18-sodium fluoride uptake was observed at 141 sites in 94 (34.9%) patients. Radiotracer accumulation was colocalized with calcification in all atherosclerotic lesions. F-18-sodium fluoride uptake was significantly associated with age (P < 0.0001), male sex (P < 0.0001), hypertension (P < 0.002), and hypercholesterolemia (P < 0.05). The presence of calcified plaque correlated significantly with these risk factors but also with diabetes (P < 0.0001), history of smoking (P = 0.03), and prior cardiovascular events (P < 0.01). There was a highly significant correlation between the presence of F-18-sodium fluoride uptake and number of present cardiovascular risk factors (r = 0.30, P < 0.0001). Conclusion: Carotid F-18-sodium fluoride uptake is a surrogate measure of calcifying carotid plaque, correlates with cardiovascular risk factors, and is more frequent in patients with a high-risk profile for atherothrombotic events but demonstrates a weaker correlation with risk factors than does calcified plaque burden. This study provides a rationale to conduct further prospective studies to determine whether F-18-sodium fluoride uptake can predict vascular events, or if it may be used to monitor pharmacologic therapy.