Effects of Daily Iron Supplementation on Motor Development and Brain Connectivity in Preterm Infants: A Diffusion Magnetic Resonance Study.
Effects of Daily Iron Supplementation on Motor Development and Brain Connectivity in Preterm Infants: A Diffusion Magnetic Resonance Study.
复制标题
DOI：
10.3389/fnins.2021.769558
复制
发表时间：
2021
影响因子：
4.3
通讯作者：
Shao J
中科院分区：
文献类型：
--
作者：
Li M;Ji C;Xuan W;Chen W;Lv Y;Liu T;You Y;Gao F;Zheng Q;Shao J
目的：本研究旨在探讨不同铁营养状态早产儿运动发育及相关脑区MRI改变的特点，并探讨每日补铁是否能促进早产儿早期运动发育。研究方法：根据新生儿期最低血红蛋白水平和3月龄sFer水平，将63例早产儿分为非贫血高血清铁蛋白组（NA-HF）和贫血低血清铁蛋白组（A-LF）。49名参与者在3个月时接受了MRI扫描和婴儿神经系统国际组合（INFANIB）。在校正年龄6个月时，这些婴儿在补充2 mg/kg/d铁后接受Peabody发育运动量表（PDMS）评估。结果：共有19名早产儿被分配到NA-HF组，44名早产儿被分配到A-LF组。3月龄时，A-LF组血清铁蛋白（sFer）水平低于NA-HF组（44.0 ± 2.8mg/L vs.65.1 ± 2.8mg/L，p < 0.05），且INFANIB评分低于NA-HF组（66.8 ± 0.9 vs.64.4 ± 0.6，p < 0.05）。NA-HF组小脑与同侧丘脑之间的结构连通性明显强于A-LF组（n = 17，109.76 ± 23.8 vs. n = 32，70.4 ± 6.6，p < 0.05）。脑结构连通性降低与PDMS评分呈正相关（r = 0.347，p < 0.05）。常规补铁6个月后，A-LF组和NA-HF组的Hb、MCV、MCHC、RDW和sFer以及PDMS-2评估的运动评分均无差异。结论：早产儿生后早期铁营养状况与运动发育和脑结构连接丰富有关。大脑结构连接的减少与运动延迟有关。在每天补充2 mg/kg铁6个月后，A-LF和NA-HF组之间的铁状况和运动能力的差异被消除。
Objectives: The aim of the study is to demonstrate the characteristic of motor development and MRI changes of related brain regions in preterm infants with different iron statuses and to determine whether the daily iron supplementation can promote motor development for preterm in early infancy. Methods: The 63 preterm infants were grouped into non-anemia with higher serum ferritin (NA-HF) group and anemia with lower serum ferritin (A-LF) group according to their lowest serum Hb level in the neonatal period as well as the sFer at 3 months old. Forty-nine participants underwent MRI scans and Infant Neurological International Battery (INFANIB) at their 3 months. At 6 months of corrected age, these infants received the assessment of Peabody Developmental Motor Scales (PDMS) after 2 mg/kg/day iron supplementation. Results: In total, 19 preterm infants were assigned to the NA-HF group while 44 preterm infants to the A-LF groups. The serum ferritin (sFer) level of the infants in A-LF group was lower than that in NA-HF group (44.0 ± 2.8 mg/L vs. 65.1 ± 2.8 mg/L, p < 0.05) and was with poorer scores of INFANIB (66.8 ± 0.9 vs. 64.4 ± 0.6, p < 0.05) at 3 months old. The structural connectivity between cerebellum and ipsilateral thalamus in the NA-HF group was significantly stronger than that in the A-LF group (n = 17, 109.76 ± 23.8 vs. n = 32, 70.4 ± 6.6, p < 0.05). The decreased brain structural connectivity was positively associated with the scores of PDMS (r = 0.347, p < 0.05). After 6 months of routine iron supplementation, no difference in Hb, MCV, MCHC, RDW, and sFer was detected between A-LF and NA-HF groups as well as the motor scores of PDMS-2 assessments. Conclusion: Iron status at early postnatal period of preterm infant is related to motor development and the enrichment of brain structural connectivity. The decrease in brain structural connectivity is related to the motor delay. After supplying 2 mg/kg of iron per day for 6 months, the differences in the iron status and motor ability between the A-LF and NA-HF groups were eliminated.
登录
查看更多内容
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
3.6
作者：
Berglund, Staffan K.;Chmielewska, Anna;Domellof, Magnus
通讯作者：
Domellof, Magnus
影响因子：
3.9
作者：
Domellof, Magnus
通讯作者：
Domellof, Magnus
DOI：
10.1002/jmri.23790
发表时间：
2013-01
期刊：
Journal of magnetic resonance imaging : JMRI
影响因子：
--
作者：
Djamanakova A;Faria AV;Hsu J;Ceritoglu C;Oishi K;Miller MI;Hillis AE;Mori S
通讯作者：
Mori S
影响因子：
5.7
作者：
Andersson JLR;Sotiropoulos SN
通讯作者：
Sotiropoulos SN