Inhibition of the replication of hepatitis B virus by the carbocyclic analogue of 2'-deoxyguanosine.
Inhibition of the replication of hepatitis B virus by the carbocyclic analogue of 2'-deoxyguanosine.
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DOI：
10.1073/pnas.86.21.8541
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发表时间：
1989-11
影响因子：
11.1
通讯作者：
Peter M. Price;Ranjit Banerjee;George Acs
中科院分区：
文献类型：
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作者：
Peter M. Price;Ranjit Banerjee;George Acs
我们报道了用2 ′-脱氧鸟苷的碳环类似物[Shealy，Y. F.、奥戴尔角一、Shannon，W. M. & Arnett，G.（1984）J.Med.Chem.27，1416-1421]导致病毒复制几乎完全停止，如通过细胞内游离型和分泌型病毒DNA的不存在以及通过病毒DNA聚合酶活性的不存在所监测的。该药物在高达最低有效抑制浓度200倍的浓度下是无毒的。
We report that treatment of 2.2.15, a human hepatoblastoma-derived cell line in which hepatitis B virus is actively replicating, with the carbocyclic analogue of 2'-deoxyguanosine [Shealy, Y. F., O'Dell, C. A., Shannon, W. M. & Arnett, G. (1984) J. Med. Chem. 27, 1416-1421] resulted in the nearly complete cessation of viral replication, as monitored by the absence of both intracellular episomal and secreted viral DNAs and by the absence of viral DNA polymerase activity. The drug was nontoxic in concentrations up to 200 times the minimum effective inhibitory concentration.