Aggression, hostility, and irritability in children at risk for bipolar disorder
Aggression, hostility, and irritability in children at risk for bipolar disorder
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DOI：
10.1111/j.1399-5618.2007.00390.x
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发表时间：
2007-08-01
影响因子：
5.4
通讯作者：
Brent, David
中科院分区：
文献类型：
--
作者：
Farchione, Tiffany R.;Birmaher, Boris;Brent, David
目的：评估双相情感障碍（BP）高危儿童的攻击性、易激惹性和敌意。方法：采用儿童敌意量表（CHI）的父母版本和儿童版本，我们评估了300名6-18岁BP父母子女和169名社区对照儿童的攻击性、敌意和易激惹性。BP父母的子女在总CHI及其分量表上的得分显著高于对照父母的子女。在调整人口统计学变量，父母双方的非BP精神病理学，儿童精神病理学，和家庭内的相关性，三个因素仍然显着：总CHI父母评级，易怒子量表父母评级，和易怒的儿童自我报告。结论：BP父母子女的敌对性和易激惹性评分高于社区对照父母子女，且与儿童精神病理学和非BP父母精神病理学无关。对这些儿童进行随访，以评估这些症状是否是BP或情绪障碍发展的标志物是必要的。
Objectives: To assess aggression, irritability and hostility in children at risk for bipolar disorder (BP).Methods: Using the parent and the child versions of the Children's Hostility Inventory (CHI), we assessed aggression, hostility, and irritability in 300 offspring aged 6-18 years old of BP parents and 169 children of community controls.Results: Children of BP parents have significantly higher scores on the total CHI and its subscales than do children of control parents. After adjusting for demographic variables, both parents' non-BP psychopathology, child psychopathology, and within-family correlations, three factors remain significant: total CHI by parent rating, irritability subscale by parent rating, and irritability by child self-report. The hostility subscale by parent rating became a trend.Conclusions: Children of BP parents score higher on ratings of hostility and irritability than children of community control parents, independent of child psychopathology and non-BP parental psychopathology. Follow-up of these children to evaluate whether these symptoms are markers for the development of BP or mood disorders is warranted.