CENP-E hangs on at dynamic microtubule ends.
CENP-E hangs on at dynamic microtubule ends.
复制标题
CENP-E 附着在动态微管末端。
DOI：
10.1038/ncb2836
复制
发表时间：
2013
影响因子：
21.3
通讯作者：
Gardner,MelissaK
中科院分区：
文献类型：
--
作者：
Gardner,MelissaK
在有丝分裂过程中，动粒附着在微管正末端，从而允许动态微管正确地分离染色体。微管加末端和动粒之间的这种“末端对”连接是如何形成和维持的尚不清楚。CENP-E是驱动蛋白-7家族成员，目前已显示在将动粒与动态微管正末端相关联中具有作用。
During mitosis, kinetochores attach to microtubule plus ends, thus allowing dynamic microtubules to properly segregate chromosomes. How this type of 'end-on' attachment between microtubule plus ends and kinetochores is formed and maintained is unclear. CENP-E, a kinesin-7 family member, is now shown to have a role in associating kinetochores with dynamic microtubule plus ends.