Pyrazinamide resistance determined by liquid culture at low pH better correlates with genetic mutations in MDR tuberculosis isolates
Pyrazinamide resistance determined by liquid culture at low pH better correlates with genetic mutations in MDR tuberculosis isolates
复制标题
低pH液体培养测定的吡嗪酰胺耐药性与耐多药结核病分离株的基因突变更好地相关
DOI：
10.1016/j.mimet.2015.10.014
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发表时间：
2015-12-01
影响因子：
2.2
通讯作者：
Zhao, Yanlin
中科院分区：
文献类型：
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作者：
Pang, Yu;Wang, Zhongdong;Zhao, Yanlin
在不同pH值的Bactec MGIT 960液体培养基中检测结核分枝杆菌菌株对吡嗪酰胺（PZA）的敏感性。结果表明，pH5.7液体培养法检测的耐药率（94.9%）与耐药株的遗传变异有较好的相关性。结核分离株（P = 0.001）。(C)2015 Elsevier B.V.版权所有。
We detected the pyrazinamide (PZA) susceptibility of Mycobacterium tuberculosis strains in the Bactec MGIT 960 liquid medium with different pH values. Our results demonstrated that PZA resistance determined by liquid culture at pH 5.7 (94.9%) showed better correlation with genetic changes among multidrug-resistant M. tuberculosis isolates (P = 0.001). (C) 2015 Elsevier B.V. All rights reserved.