Cell therapies for liver diseases.

Cell therapies for liver diseases.
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DOI:
10.1002/lt.22467
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发表时间:
2012-01
影响因子:
4.6
通讯作者:
Nyberg, Scott L.
Nyberg, Scott L.
中科院分区:
医学2区
文献类型:
--
作者:
Yu, Yue;Fisher, James E.;Lillegard, Joseph B.;Rodysill, Brian;Amiot, Bruce;Nyberg, Scott L.

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细胞疗法,包括生物人工肝支持和肝细胞移植,已成为多种肝脏疾病的潜在治疗方法。急性肝衰竭(ALF)、慢加急性肝衰竭以及遗传性代谢性肝病是世界各地一些中心已成功用细胞疗法治疗的肝脏疾病实例。细胞疗法在其他肝脏疾病(包括非遗传性肝病和肝癌)以及提高肝移植成功率方面也具有广泛应用的潜力。在此我们简要概述当前肝脏疾病细胞疗法的概念。
Cell therapies, which include bioartificial liver support and hepatocyte transplantation, have emerged as potential treatments for a variety of liver diseases. Acute liver failure (ALF), acute-on-chronic liver failure, and inherited metabolic liver diseases are examples of liver diseases that have been successfully treated with cell therapies at centers around the world. Cell therapies also have the potential for wide application in other liver diseases, including non-inherited liver diseases and liver cancer, and in improving the success of liver transplantation. Here we briefly summarize current concepts of cell therapy for liver diseases.
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