Easy Hi-C: A Low-Input Method for Capturing Genome Organization.
Easy Hi-C: A Low-Input Method for Capturing Genome Organization.
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DOI：
10.1007/978-1-0716-2847-8_9
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发表时间：
2023
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Chromosome conformation capture technology and its derivatives have been widely used to study genome organization. Among them, Hi-C (chromosome conformation capture coupling with high-throughput sequencing) is popular in dissecting chromatin architecture on the genome-wide level. However, the intrinsic limitations prevent its application when comes to rare samples. Here, we present easy Hi-C, a biotin-free technology, which dramatically reduces DNA loss and is suitable for low-input samples.
