The occurrence of intercellular bridges in groups of cells exhibiting synchronous differentiation.
The occurrence of intercellular bridges in groups of cells exhibiting synchronous differentiation.
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在表现出同步分化的细胞组中，细胞间桥的发生。
DOI：
10.1083/jcb.5.3.453
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发表时间：
1959-05-25
期刊：
影响因子：
--
通讯作者：
SLAUTTERBACK, D
中科院分区：
文献类型：
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作者：
FAWCETT, D W;ITO, S;SLAUTTERBACK, D
先前对猫睾丸的电子显微镜研究显示，来自同一精原细胞的精子细胞通过细胞间桥连接在一起。本文记录了水螅、果蝇、负鼠、鸽子、大鼠、仓鼠、豚鼠、兔、猴和人的精母细胞和精子细胞之间的类似连接。鉴于这些发现，我们认为，在发育中的雄性生殖细胞群中，合胞体关系可能是普遍发生的，并可能是它们同步分化的原因。当精子细胞，新鲜分离的生殖上皮细胞簇观察相差显微镜，合胞体的细胞单位之间的收缩消失，整个集团合并成一个球形的多核质量。本文还讨论了这一观察结果与精液中异常精子的发生和病理性睾丸中多核巨细胞的患病率之间的关系。在水螅的外胚层中，由间质细胞增殖产生的成刺细胞簇也通过细胞间桥连接。在这些相连的细胞群中，包囊的发育是精确同步的。在脊椎动物的睾丸和水螅的外胚层中，合胞体都是由相对未分化的细胞增殖中不完全的胞质分裂引起的。当分裂沟遇到纺锤体残体并被其阻止时，子细胞之间形成细胞间桥，随后纺锤体丝的溶解建立了细胞之间的自由交流。在这里讨论的两个不相关的组织中发现的细胞间桥表明，在自然界的其他地方可能会发现类似的合胞体关系，其中共同起源的细胞群同步分化。
A previous electron microscopic study of the cat testis revealed that spermatids derived from the same spermatogonium are joined together by intercellular bridges. The present paper records the observation of similar connections between spermatocytes and between spermatids in Hydra, fruit-fly, opossum, pigeon, rat, hamster, guinea pig, rabbit, monkey, and man. In view of these findings, it is considered likely that a syncytial relationship within groups of developing male germ cells is of general occurrence and is probably responsible for their synchronous differentiation. When clusters of spermatids, freshly isolated from the germinal epithelium are observed by phase contrast microscopy, the constrictions between the cellular units of the syncytium disappear and the whole group coalesces into a spherical multinucleate mass. The significance of this observation in relation to the occurrence of abnormal spermatozoa in semen and the prevalence of multinucleate giant cells in pathological testes is discussed. In the ectoderm of Hydra, the clusters of cnidoblasts that arise from proliferation of interstitial cells are also connected by intercellular bridges. The development of nematocysts within these groups of conjoined cells is precisely synchronized. Both in the testis of vertebrates and the ectoderm of Hydra, a syncytium results from incomplete cytokinesis in the proliferation of relatively undifferentiated cells. The intercellular bridges between daughter cells are formed when the cleavage furrow encounters the spindle remnant and is arrested by it. The subsequent dissolution of the spindle filaments establishes free communication between the cells. The discovery of intercellular bridges in the two unrelated tissues discussed here suggests that a similar syncytial relationship may be found elsewhere in nature where groups of cells of common origin differentiate synchronously.