Osteochondromas and growth retardation secondary to externally or internally administered radiation in childhood
Osteochondromas and growth retardation secondary to externally or internally administered radiation in childhood
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DOI：
10.1007/s00247-006-0382-0
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发表时间：
2007-03-01
影响因子：
2.3
通讯作者：
Liebling, Melissa S.
中科院分区：
文献类型：
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作者：
Marcovici, Peter A.;Berdon, Walter E.;Liebling, Melissa S.
五十多年来，骨软骨瘤(外生骨软骨病)和相关的生长迟缓已被认为是由辐射损伤生长的骨骼引起的。患者可分为三个暴露组。第一组接受外照射治疗，主要用于治疗儿童癌症(典型剂量为3,500cGy.)，6-20%的人出现骨软骨瘤和放射门户内的生长迟缓。第二组是最近报道的接受全身照射为骨髓移植做准备的患者(典型剂量：800-1200cGy)，约20%的患者出现骨软骨瘤和生长迟缓。第三组包括206名德国儿童，他们在20世纪40年代和50年代初接受了静脉放射性Peteosthor(Ra-224)治疗骨结核(估计典型剂量：1,000-2,000 cGy)，14%的儿童出现骨软骨瘤和生长迟缓，以及其他良、恶性后遗症。将这三个暴露组结合起来，至少有6-20%的接受放射治疗的儿童会出现骨软骨瘤和生长迟缓，这些儿童的骨骼正在发育。
For over five decades, osteochondromas (exostoses) and associated growth retardation have been known to be caused by radiation damage to the growing skeleton.Patients can be divided into three exposure groups. Group I received external beam radiation therapy primarily for the treatment of childhood cancers (typical dose 3,500 cGy), and 6-20% developed osteochondromas and growth retardation within the radiation portal. Group II consists of recently described patients who received total body irradiation in preparation for bone marrow transplant (typical dose: 800-1,200 cGy), and about 20% developed osteochondromas and growth retardation. Group III consists of 206 German children who in the 1940s and early 1950s received intravenous radioactive Peteosthor (Ra-224) to treat bone tuberculosis (estimated typical dose: 1,000-2,000 cGy), and 14% developed osteochondromas and growth retardation, among other benign and malignant sequelae. Combining these three exposure groups, osteochondromas and growth retardation develop in at least 6-20% of children who receive therapeutic radiation to their growing skeletons.