Biosynthetic relationships of big and little gastrins
Biosynthetic relationships of big and little gastrins
复制标题
大胃泌素和小胃泌素的生物合成关系
作者：
Gj. Dockray;C. Vaillant;Colin R. Hopkins
越来越多的证据表明，许多肽激素最初是作为较大前体分子的一部分合成的。也有证据表明，几种不同的肽，如促肾上腺皮质激素、β脂促激素、黑素和内啡肽，可能是由一个前体分子在不同的分泌系统中经过不同的处理而产生的。因此，大前体的翻译后加工似乎在决定最终分泌产物的生物活性方面起着调节作用。我们已经检查了胃泌素在猪胃窦粘膜的主要生物活性形式之间的关系。
ACCUMULATING evidence suggests that many peptide hormones are synthesised initially as part of larger precursor molecules1. There is also evidence that several different peptides, for example, corticotrophin, β lipotrophin, the melanotrophins and the endorphins may arise from a single precursor molecule which is processed differently in different secretory systems2. The post-translational processing of large precursors would therefore seem to play a regulatory role in determining the biological activity of the final secretory product. We have examined the relationships between the principal biologically active forms of the hormone gastrin in porcine antral mucosa.