Antigen-bearing dendritic cells from the sublingual mucosa recirculate to distant systemic lymphoid organs to prime mucosal CD8 T cells
Antigen-bearing dendritic cells from the sublingual mucosa recirculate to distant systemic lymphoid organs to prime mucosal CD8 T cells
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DOI：
10.1038/mi.2013.45
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发表时间：
2014-03-01
影响因子：
8
通讯作者：
Anjuere, F.
中科院分区：
文献类型：
--
作者：
Hervouet, C.;Luci, C.;Anjuere, F.
效应器T细胞被描述为在淋巴结内被启动，引流免疫部位，并再循环到效应器部位。舌下免疫产生的效应性T细胞能够传播到生殖道。在这里，我们报告了另一种机制，涉及携带抗原的树突状细胞(DC)在遥远的淋巴器官中再循环，以启动T细胞。舌下免疫不能通过淋巴或血管扩散的粘附性模型抗原诱导生殖器CD8 T细胞。舌下引流的淋巴结并不是产生这些淋巴细胞的强制条件，来自远处淋巴结和脾的携带抗原的DC能够以时间和剂量依赖的方式激活特定的CD8T细胞。本研究首次证实了来自免疫部位的携带抗原的DC可再循环至远处的淋巴器官，并为舌下免疫产生远处CD8 T细胞的机制提供了新的见解。
Effector T cells are described to be primed in the lymph nodes draining the site of immunization and to recirculate to effector sites. Sublingual immunization generates effector T cells able to disseminate to the genital tract. Herein, we report an alternative mechanism that involves the recirculation of antigen-bearing dendritic cells (DCs) in remote lymphoid organs to prime T cells. Sublingual immunization with a muco-adhesive model antigen unable to diffuse through lymphatic or blood vessels induced genital CD8 T cells. The sublingual draining lymph nodes were not mandatory to generate these lymphocytes, and antigen-bearing DCs from distant lymph nodes and spleen were able to prime specific CD8 T cells in a time- and dose-dependent manner. This study demonstrates, for the first time, that antigen-bearing DCs originating from the site of immunization recirculate to distant lymphoid organs and provides insights into the mechanism of distant CD8 T-cell generation by sublingual immunization.