Homogeneous two-component polycondensation without strict stoichiometric balance via the Tsuji-Trost reaction: remote control of two reaction sites by catalysis.
Homogeneous two-component polycondensation without strict stoichiometric balance via the Tsuji-Trost reaction: remote control of two reaction sites by catalysis.
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DOI：
10.1021/ja0492743
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发表时间：
2004-04
影响因子：
15
通讯作者：
N. Nomura;K. Tsurugi;T. RajanBabu;T. Kondo
中科院分区：
文献类型：
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作者：
N. Nomura;K. Tsurugi;T. RajanBabu;T. Kondo
卡罗瑟斯和弗洛里建立了均相双组分缩聚反应的基本原理，通过这种反应，各种常用的聚合物，如聚酯和聚酰胺（尼龙），直到现在都可以合成。实现高度聚合的最关键因素之一是严格遵守两组分的化学计量平衡。两种原料的比例不平衡导致聚合程度较低，从而导致聚合物质量差。在这里，我们报告了一种策略的细节，通过适当的实验验证，该策略通过钯催化的烯丙基取代（Tsuji-Trost）反应实现了高效的均相双组分缩聚，而无需严格的化学计量平衡。
Carothers and Flory established the fundamental principles of homogeneous two-component polycondensation reactions by which a variety of commonly used polymers such as polyesters and polyamides (nylons) are synthesized even now. One of the most critical factors to achieve a high degree of polymerization is a strict adherence of stoichiometric balance of the two components. An imbalanced ratio of the two starting materials leads to lower degree of polymerization and, consequently, polymers of poor quality. Here we report the details of a strategy, validated by appropriate experiments, which enables an efficient homogeneous two-component polycondensation via palladium-catalyzed allylic substitution (the Tsuji-Trost) reaction without strict stoichiometric balance.