Theta and High-Frequency Activity Mark Spontaneous Recall of Episodic Memories
Theta and High-Frequency Activity Mark Spontaneous Recall of Episodic Memories
复制标题
DOI：
10.1523/jneurosci.2654-13.2014
复制
发表时间：
2014-08-20
影响因子：
5.3
通讯作者：
Kahana, Michael J.
中科院分区：
文献类型：
--
作者：
Burke, John F.;Sharan, Ashwini D.;Kahana, Michael J.
人类拥有搜索记忆的非凡能力，可以自发地重新体验特定的过去事件。在这里，我们对114名神经外科患者进行了自由回忆测试，并使用颅内θ波和高频活动（HFA）来识别自发性情景检索背后的神经活动的时空模式。我们发现，提取过程分为三个电生理阶段：（1）右颞叶皮层的早期θ振荡，（2）左半球包括内侧颞叶（MTL）、左额下回以及腹外侧颞叶皮层的HFA增加，（3）在提取项目的发声过程中运动/语言激活。在这些反应中，左MTL中HFA的增加预测了回忆性能。这些结果表明，口头情景记忆的自发回忆涉及整个大脑的频谱变化的时空模式，然而，在左侧MTL的高频活动是情景检索的最终共同途径。
Humans possess the remarkable ability to search their memory, allowing specific past episodes to be re-experienced spontaneously. Here, we administered a free recall test to 114 neurosurgical patients and used intracranial theta and high-frequency activity (HFA) to identify the spatiotemporal pattern of neural activity underlying spontaneous episodic retrieval. We found that retrieval evolved in three electrophysiological stages composed of: (1) early theta oscillations in the right temporal cortex, (2) increased HFA in the left hemisphere including the medial temporal lobe (MTL), left inferior frontal gyrus, as well as the ventrolateral temporal cortex, and (3) motor/language activation during vocalization of the retrieved item. Of these responses, increased HFA in the left MTL predicted recall performance. These results suggest that spontaneous recall of verbal episodic memories involves a spatiotemporal pattern of spectral changes across the brain; however, high-frequency activity in the left MTL represents a final common pathway of episodic retrieval.