The minimum number of neurons in the central olfactory pathway in relation to its function: a retrograde fiber tracing study.
The minimum number of neurons in the central olfactory pathway in relation to its function: a retrograde fiber tracing study.
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中枢嗅觉通路中神经元的最小数量与其功能相关：逆行纤维追踪研究。
DOI：
10.1093/chemse/27.1.1
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发表时间：
2002
期刊：
影响因子：
3.5
通讯作者：
T. Moriizumi
中科院分区：
文献类型：
--
作者：
N. Fukushima;S. Oikawa;K. Yokouchi;K. Kawagishi;T. Moriizumi
本研究旨在确定中枢嗅觉神经系统中神经元群体的功能基本大小。使用条件的大鼠谁学会了避免驱虫剂（放线菌酮）解决方案的嗅觉，不同程度的损伤进行了外侧嗅道，一个主要的中央嗅觉通路连接嗅球的嗅觉皮层。在检查他们的嗅觉能力，区分放线菌酮溶液从水，完整的延髓投射神经元（二尖瓣细胞）与嗅觉皮质的纤维连接进行了定量使用逆行纤维追踪技术。嗅觉正常大鼠的逆行标记二尖瓣细胞数量为对照值的20 - 92%，而嗅觉缺失大鼠的这些数量为0 - 22%。我们的结论是，功能上必不可少的神经元人口是大约五分之一的总在中央嗅觉通路，一个假定的阈值方面的能力，以避免放线菌酮解决方案的嗅觉歧视。
The present study was aimed at determining the functionally essential size of the neuronal population in the central olfactory nervous system. Using conditioned rats who had learnt to avoid repellent (cycloheximide) solution by olfaction, varying degrees of injuries were made to the lateral olfactory tract, a major central olfactory pathway connecting the olfactory bulb to the olfactory cortex. After examining their olfactory ability to discriminate cycloheximide solution from water, intact bulbar projection neurons (mitral cells) with fiber connections to the olfactory cortex were quantified using a retrograde fiber tracing technique. The numbers of retrogradely labeled mitral cells from the rats with normal olfaction ranged between 20 and 92% of the control value, while those numbers from the anosmic rats ranged between 0 and 22%. We conclude that the functionally essential neuronal population is approximately one-fifth of the total in the central olfactory pathway, a presumed threshold value in terms of the ability to avoid cycloheximide solution by olfactory discrimination.