Kaempferide-7-O-(4"-O-acetylrhamnosyl)-3-O-rutinoside reduces myocardial infarction Size after coronary artery ligation in rats
Kaempferide-7-O-(4"-O-acetylrhamnosyl)-3-O-rutinoside reduces myocardial infarction Size after coronary artery ligation in rats
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DOI：
10.1691/ph.2013.2913
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发表时间：
2013-06-01
期刊：
影响因子：
1.6
通讯作者：
Sui, Dayuan
中科院分区：
文献类型：
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作者：
Eerduna, Gaowa;Wei, Dongsheng;Sui, Dayuan
山奈素-7- o -（4′- o -乙酰鼠李糖）-3- o -rutinoside （a - f - b）是从猕猴桃叶中提取的一种新型类黄酮。我们最近报道了A-F-B给药可以改善血脂。A-F-B的作用与调节肝组织中PAP和HMG-CoA还原酶的活性有关。本研究评价了A-F-B对大鼠急性心肌梗死（AMI）的影响。结扎左冠状动脉前降支建立AMI模型。测定心肌梗死面积（MIS）、肌酸激酶（CK-MB）活性、肌钙蛋白T水平、内皮型一氧化氮合酶（eNOS）活性、超氧化物歧化酶（SOD）活性、过氧化氢酶活性、丙二醛（MDA）含量、一氧化氮（NO）含量。结果显示，a - f - b组MIS呈剂量依赖性降低。A-F-B能显著抑制心肌梗死引起的CK-MB活性升高、肌钙蛋白T水平升高和MDA含量升高。a - f - b还显示出提高SOD、过氧化氢酶和eNOS活性的能力。a - f - b处理组一氧化氮含量也增加。提示A-F-B通过调节抗氧化酶活性和内皮型一氧化氮合酶活性，对急性心肌缺血损伤具有心脏保护作用。
Kaempferide-7-O-(4"-O-acetylrhamnosyl)-3-O-rutinoside (A-F-B) is a novel flavonoid extracted from the leaves of Actinidia kolomikta. We recently reported that A-F-B administration could improve lipid profiles. A-F-B actions are associated with regulating the activities of PAP and HMG-CoA reductase in hepatic tissue. This study evaluated the effects of A-F-B on acute myocardial infarction (AMI) in rats. An AMI model was established by ligating the left anterior descending coronary artery. The myocardial infarct size (MIS), creatine kinase (CK-MB) activity, troponin T level, endothelial nitric oxide synthase (eNOS) activity, superoxide dismutase (SOD) activity, catalase activity, malondialdehyde (MDA) content, nitric oxide (NO) content were measured. The results showed that the groups treated with A-F-B showed a dose-dependent reduction in MIS. A-F-B markedly inhibited the elevation of the activity of CK-MB, troponin T level, and the content of MDA induced by AMI. A-F-B also showed a capacity to increase the activities of SOD, catalase, and eNOS. The NO content in A-F-B-treated groups also augmented. The findings suggest that A-F-B exerted cardioprotective effects against acute myocardial ischemic injury by regulating antioxidative enzymes activity and endothelial nitric oxide synthase activity.