PROPHYLACTIC NECK DISSECTION IN SQUAMOUS-CELL CARCINOMA OF ORAL TONGUE - A PROSPECTIVE RANDOMIZED STUDY
PROPHYLACTIC NECK DISSECTION IN SQUAMOUS-CELL CARCINOMA OF ORAL TONGUE - A PROSPECTIVE RANDOMIZED STUDY
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DOI：
10.1002/ssu.2980050507
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发表时间：
1989-01-01
期刊：
影响因子：
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通讯作者：
PATEL, AR
中科院分区：
文献类型：
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作者：
FAKIH, AR;RAO, RS;PATEL, AR
本文介绍了正在进行的口腔舌癌T1T2N0早期前瞻性随机临床试验的第一份报告。在这次试验中，通过密切的个人后续行动，成功地克服了对印度广大农村贫困人口进行定期后续行动的问题。这项试验专门针对T1T2N0口腔舌癌患者的颈部预防性和治疗性外科治疗。在接受预防性颈淋巴清扫组中，总体疾病、无病生存期(中位随访期22个月)较高(%对47%)。预防性颈淋巴清扫术阳性的患者的无瘤存活率是随后接受治疗性颈清扫术的患者的两倍(57%比28%)。在那些同时接受预防性颈淋巴清扫术的患者中，对侧颈淋巴结转移已被确定为颈部失败的重要因素。
This paper presents the first report of an ongoing prospective randomised clinical trial in early T1T2N0carcinoma of the oral tongue. The problems of regular follow‐up in an indigent population from the vast rural expanse of India has been successfully overcome in this trial by close personal follow‐up. The trial addresses itself specifically to prophylactic vs. therapeutic surgical management of the neck in T1T2N0patients with cancer of the oral tongue. Overall disease, free survival (median follow‐up 22 months) is higher (64% vs. 47%) in the group receiving prophylactic neck dissection. Disease‐free survival for those with positive nodes at prophylactic neck dissection was twice that of those who underwent a subsequent therapeutic neck dissection (57% vs. 28%).Contralateral neck node metastasis has been identified as a significant factor in neck failures in those patients undergoing simultaneous prophylactic neck dissection.