OUP accepted manuscript
OUP accepted manuscript
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自我与他人的区别对于人类互动至关重要。虽然结果相互矛盾，但研究发现，催产素（OT）使自我-他人感知边界变得尖锐。然而，关于OT对自我-他人知觉的影响，特别是其神经基础，目前还知之甚少。此外，尚不清楚当他人是儿童或成人时，OT是否会影响自我-他人歧视。本研究采用双盲、安慰剂对照研究，从行为和神经层面探讨了OT对自我面孔知觉的影响。对于刺激，我们变形了参与者的脸和儿童或成人陌生人的脸，导致4种情况。在接受OT或安慰剂治疗后，参与者报告在使用功能性磁共振成像（fMRI）进行扫描时刺激是否与自己相似。行为结果表明，人们判断成人变形的脸比儿童变形的脸更好。此外，功能磁共振成像结果显示，OT组表现出增加的视觉区和额下回的活动，为自我面孔。这种差异在成人面孔条件下更为明显。在多变量功能磁共振成像和感兴趣区域分析中，OT组的表现更好，表明OT增加了自我-他人的区别，特别是对于成年人的面孔和左半球。我们的研究显示了OT对自我参照过程的显著影响，证明了OT对左半球自我网络的潜在影响。
Self–other distinction is crucial for human interaction. Although with conflicting results, studies have found that oxytocin (OT) sharpens the self–other perceptual boundary. However, little is known about the effect of OT on self–other perception, especially its neural basis. Moreover, it is unclear whether OT influences self–other discrimination when the other is a child or an adult. This double-blind, placebo-controlled study investigated the effect of OT on self-face perception at the behavioral and neural levels. For the stimuli, we morphed participants’ faces and child or adult strangers’ faces, resulting in 4 conditions. After treatment with either OT or placebo, participants reported whether a stimulus resembled themselves while being scanned using functional magnetic resonance imaging (fMRI). Behavioral results showed that people judged adult-morphed faces better than child-morphed faces. Moreover, fMRI results showed that the OT group exhibited increased activity in visual areas and the inferior frontal gyrus for self-faces. This difference was more pronounced in the adult-face condition. In multivariate fMRI and region of interest analyses, better performance in the OT group indicated that OT increased self–other distinction, especially for adult faces and in the left hemisphere. Our study shows a significant effect of OT on self-referential processes, proving the potential effect of OT on a left hemisphere self-network.