Functional difference between rat perirhinal cortex and hippocampus in object and place discrimination tasks
Functional difference between rat perirhinal cortex and hippocampus in object and place discrimination tasks
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DOI：
10.1016/j.bbr.2008.10.012
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发表时间：
2009-02-11
影响因子：
2.7
通讯作者：
Iwasaki, Tsuneo
中科院分区：
文献类型：
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作者：
Abe, Hiroshi;Ishida, Yasushi;Iwasaki, Tsuneo
本研究旨在探讨大鼠嗅周皮层和海马在物体和地点辨别任务中的参考记忆表现的功能分离程度。在一个实验中，30只大鼠在高架径向臂迷宫中进行两对并发物体辨别任务的训练。与对照组和海马损伤组相比，嗅周皮质损伤组大鼠需要更多的时间才能达到术前获得性物体辨别任务再学习的标准。但术后3组在学习原物体辨别任务和新辨别任务以及再学习中达到标准的时间差异无统计学意义。海马损伤的大鼠在物体辨别方面没有表现出任何损害。在第二个实验中，27只大鼠在同一个迷宫中接受了位置辨别任务的训练。海马损伤的大鼠需要更多的时间来达到标准比对照组大鼠重新学习术前获得的位置歧视任务，他们有更少的正确反应，在前三届与新的歧视比对照组大鼠。另一方面，有嗅周皮质损伤的大鼠表现出轻度的再学习障碍。这些结果表明，在物体和地点辨别任务中，在参考记忆的表现上，在嗅周皮层和海马之间存在功能上的单一分离。他们还建议可能涉及的嗅周皮层在空间参考记忆的性能。(C)2008 Elsevier B.V.保留所有权利。
The present study was designed to determine the degree of functional dissociation between the rat perirhinal cortex and hippocampus for reference memory performance on object and place discrimination tasks. In one experiment, 30 rats were trained on a two-pair concurrent object discrimination task in an elevated radial arm maze. Rats with a perirhinal cortex lesion needed significantly more days to attain the criterion in the relearning of a pre-operatively acquired object discrimination task than the control rats and rats with a hippocampal lesion. However, there were no significant differences between the three groups in the days to attain the criterion in learning post-operatively the original object discrimination task with new discriminanda and its relearning. The rats with a hippocampal lesion did not show any impairment in object discrimination. In a second experiment, 27 rats were trained on a place discrimination task in the same maze. Rats with a hippocampal lesion required more days to attain the criterion than the control rats to relearn the pre-operatively acquired place discrimination task, and they had fewer correct responses in the first three sessions with new discriminanda than the control rats. Rats with a perirhinal cortex lesion, on the other hand, showed mild relearning impairment. These results suggest that there is a functionally single dissociation between the perirhinal cortex and hippocampus for reference memory performance on object and place discrimination tasks. They also suggest the possible involvement of the perirhinal cortex in spatial reference memory performance. (C) 2008 Elsevier B.V. All rights reserved.