MXene Composite Nanofibers for Cell Culture and Tissue Engineering
MXene Composite Nanofibers for Cell Culture and Tissue Engineering
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DOI：
10.1021/acsabm.0c00007
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发表时间：
2020-04-20
影响因子：
4.7
通讯作者：
Jin, Lin
中科院分区：
文献类型：
--
作者：
Huang, Rongkang;Chen, Xing;Jin, Lin
MXene 因其出色的性能而成为非常有前途的新兴材料，适用于多种应用。然而，MXene 对细胞生长和分化的影响几乎没有研究。在这里，我们制造了碳化钛（Ti3C2）MXene复合纳米纤维作为细胞培养和组织工程的智能生物材料。通过静电纺丝和掺杂制备的复合纳米纤维由于引入了大量功能性亲水基团而表现出优异的亲水性。 MXene复合纳米纤维的纳米表面和官能团为细胞生长提供了良好的微环境。应用骨髓间充质干细胞（BMSC）来评估其生化特性。细胞测试结果表明，所获得的MXene复合纳米纤维具有良好的生物相容性，并且大大提高了细胞活性。这些复合纳米纤维增强了 BMSC 向成骨细胞的分化。 MXene 优异的生物相容性与纳米效应相结合，表明这种新型生物材料有潜力弥合材料科学和基于干细胞的组织疗法以及基于 MXene 独特优势的未来多任务生物医学疗法的转化差距。
MXenes are very promising emerging materials for diverse applications because of their outstanding properties. However, the effect of MXene on cell growth and differentiation had barely been studied. Here, we fabricated titanium carbide (Ti3C2) MXene composite nanofibers as smart biomaterials for cell culture and tissue engineering. The composite nanofibers were fabricated by electro-spinning and doping and displayed excellent hydrophilicity because of a large number of introduced functional hydrophilic groups. The nanosurface and functional groups of MXene composite nanofibers provide a good microenvironment for cellular growth. Bone marrow-derived mesenchymal stem cells (BMSCs) were applied to assess their biochemical properties. The cell test outcome demonstrated that the obtained MXene composite nanofibers had good biocompatibility and greatly improved cellular activity. These composite nanofibers enhanced BMSC's differentiation to osteoblasts. The excellent biocompatibility combined with the nanoeffect of MXene suggested that this novel class of biomaterials has the potential to bridge the translational gap in materials sciences and stem cell-based tissue therapies and future multitask biomedical therapies based on MXene's unique advantages.