Bacteria may be in the liver, but the jury is still out.
Bacteria may be in the liver, but the jury is still out.
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DOI：
10.1172/jci158999
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发表时间：
2022-04-15
期刊：
影响因子：
--
通讯作者：
Nagy L
中科院分区：
文献类型：
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作者：
Broderick NA;Nagy L
A fundamental and highly contested issue in microbiome research is whether internal organs such as the liver, brain, placenta, pancreas, and others are sterile and privileged or harbor a detectable and functional microbial biomass. In this issue of the JCI, Leinwand, Paul, et al. addressed this question using an array of diverse techniques and reported that normal healthy liver possesses a microbiome that is selectively recruited from the gut. They further showed that liver-enriched microbes contributed to shaping the immune network of this organ. Here, we attempt to put their findings into the context of other organs, discuss the technical challenges of defining such microbial communities, and provide some perspective about the road ahead for the field.
