Role of potassium ion channels in detrusor smooth muscle function and dysfunction.
Role of potassium ion channels in detrusor smooth muscle function and dysfunction.
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DOI：
10.1038/nrurol.2011.194
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发表时间：
2011-12-13
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影响因子：
--
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构成膀胱壁的逼尿肌平滑肌 (DSM) 的收缩和舒张有利于尿液的储存和排泄。多个 K+ 通道家族，包括电压门控 K+ (KV) 通道、Ca2+ 激活 K+ (KCa) 通道、内向整流 ATP 敏感 K+ (Kir、KATP) 通道和双孔域 K+ (K2P) 通道，在 DSM 中表达并发挥功能。它们通过维持静息膜电位和塑造决定该组织收缩性相位性质的动作电位来控制 DSM 兴奋性和收缩性。 DSM K+通道蛋白或参与其调节途径的分子的缺陷可能是某些形式的膀胱功能障碍的基础，例如膀胱过度活动症。 K+ 通道为人类 DSM 中新型药理操作和治疗干预提供了机会。通过针对其调节机制直接或间接调节 DSM K+ 通道具有控制膀胱功能的潜力。本综述总结了我们目前对 DSM 中 K+ 通道在健康和疾病中的功能作用的了解，特别强调了该领域的当前进展。
Contraction and relaxation of the detrusor smooth muscle (DSM), which makes up the wall of the urinary bladder, facilitates the storage and voiding of urine. Several families of K+ channels, including voltage-gated K+ (KV) channels, Ca2+-activated K+ (KCa) channels, inward-rectifying ATP-sensitive K+ (Kir, KATP) channels, and two-pore-domain K+ (K2P) channels, are expressed and functional in DSM. They control DSM excitability and contractility by maintaining the resting membrane potential and shaping the action potentials that determine the phasic nature of contractility in this tissue. Defects in DSM K+ channel proteins or in the molecules involved in their regulatory pathways may underlie certain forms of bladder dysfunction, such as overactive bladder. K+ channels represent an opportunity for novel pharmacological manipulation and therapeutic intervention in human DSM. Modulation of DSM K+ channels directly or indirectly by targeting their regulatory mechanisms has the potential to control urinary bladder function. This Review summarizes our current state of knowledge of the functional role of K+ channels in DSM in health and disease, with special emphasis on current advancements in the field.
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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发表时间：
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