Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric modulation in angiotensin receptors: IUPHAR Review 34.
Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric modulation in angiotensin receptors: IUPHAR Review 34.
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DOI：
10.1111/bph.15840
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发表时间：
2022-09
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
“功能进展”引导我们了解激素血管紧张素 II (AngII) 及其拮抗剂的生理和致命病理机制。这些研究表明，组织对给定剂量的激素或其拮抗剂的反应取决于与配体结合的受体。因此，对高分辨率受体-配体复合物状态的理性好奇是相关的。最近，与肽和非肽配体结合的 AngII 受体（AT1 受体和 AT2 受体）的 X 射线结构已被阐明，为检查受体 3D 结构中的动态通量作为配体选择性、功效和受体分子功能调节的基础提供了新的机会。组成结构基序协同地将配体选择性转化为特定功能，从而概念化 3D 结构相对于受体单个基序的首要地位。这篇综述涵盖了阐明 AngII 受体结构动力学的创新以及结构知识如何能够变革性地理解 AngII 生理学机制。
“Functional advances” guided our knowledge of physiological and fatal pathological mechanisms of hormone Angiotensin II (AngII) and its antagonists. Such studies revealed that tissue response to a given dose of the hormone or its antagonist depends on receptors that engage the ligand. Thus rational curiosity about the statuses of receptor-ligand complexes in high resolution is pertinent. Recently X-ray structures of both AngII receptors (AT1 receptor and AT2 receptor) bound to peptide and non-peptide ligands have been elucidated, providing a new opportunity to examine the dynamic fluxes in the receptor’ 3D architecture as the basis of ligand selectivity, efficacy and regulation of receptor’s molecular functions. Constituent structural motifs cooperatively transform ligand selectivity into specific functions, thus conceptualizing the primacy of the 3D-structure over individual motifs of receptors. This review covers the innovations elucidating structure-dynamics of AngII receptors and how structural knowledge can be transformative in understanding the mechanisms of AngII physiology.
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影响因子：
5.8
作者：
Connolly, Alexandre;Holleran, Brian J.;Leduc, Richard
通讯作者：
Leduc, Richard
影响因子：
64.8
作者：
Jumper J;Evans R;Pritzel A;Green T;Figurnov M;Ronneberger O;Tunyasuvunakool K;Bates R;Žídek A;Potapenko A;Bridgland A;Meyer C;Kohl SAA;Ballard AJ;Cowie A;Romera-Paredes B;Nikolov S;Jain R;Adler J;Back T;Petersen S;Reiman D;Clancy E;Zielinski M;Steinegger M;Pacholska M;Berghammer T;Bodenstein S;Silver D;Vinyals O;Senior AW;Kavukcuoglu K;Kohli P;Hassabis D
通讯作者：
Hassabis D
DOI：
10.1016/0006-291x(89)91054-1
发表时间：
1989-11-30
影响因子：
3.1
作者：
CHIU, AT;HERBLIN, WF;TIMMERMANS, PBMWM
通讯作者：
TIMMERMANS, PBMWM
DOI：
10.1073/pnas.1500895112
发表时间：
2015-07-07
影响因子：
11.1
作者：
Fay, Jonathan F.;Farrens, David L.
通讯作者：
Farrens, David L.
影响因子：
13
作者：
Felker, G. Michael;Butler, Javed;Pang, Peter S.
通讯作者：
Pang, Peter S.