Effectiveness and safety of long-term antidepressant treatment in bipolar disorder
Effectiveness and safety of long-term antidepressant treatment in bipolar disorder
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DOI：
10.4088/jcp.v62n07a12
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发表时间：
2001-07-01
影响因子：
5.3
通讯作者：
Baldessarini, RJ
中科院分区：
文献类型：
--
作者：
Ghaemi, SN;Lenox, MS;Baldessarini, RJ
目的：方法：我们对MEDLINE、HealthStar、Current Contents、PsychInfo和National Library of Medicine数据库进行了计算机文献检索，以确定1966年至2000年发表的关于双相情感障碍或躁狂抑郁症患者使用抗抑郁药、抗惊厥药或锂的研究。结果：只有7个双相障碍的长期抗抑郁治疗的盲法，对照试验被发现。现有的信息是不足以支持的安全性或有效性的长期抗抑郁治疗双相抑郁症，有或没有情绪稳定cotheals.Conclusion：抗抑郁治疗双相抑郁症是非常不足的研究。需要进行对照试验，比较特定的抗抑郁药，特别是比较情绪稳定剂单独给药和与抗抑郁药联合给药。
Objective: We sought to review research on use of antidepressants for long-term treatment of bipolar depression.Method: We conducted a computerized literature search of the MEDLINE, HealthStar, Current Contents, PsychInfo, and National Library of Medicine databases to identify studies involving antidepressant, anticonvulsant, or lithium use in bipolar disorder or manic-depressive illness published from 1966 through 2000.Results: Only 7 blinded, controlled trials of long-term antidepressant treatment in bipolar disorders were found. The available information is not adequate to support the safety or effectiveness of long-term antidepressant treatment for bipolar depression, with or without mood-stabilizing cotherapy.Conclusion: Antidepressant treatment of bipolar depression is extraordinarily understudied. Controlled trials comparing specific antidepressants, particularly to compare mood-stabilizing agents given alone and combined with an antidepressant, are needed.