Commentary: building an evidence base for mendelian randomization studies: assessing the validity and strength of proposed genetic instrumental variables.
Commentary: building an evidence base for mendelian randomization studies: assessing the validity and strength of proposed genetic instrumental variables.
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评论：为孟德尔随机化研究建立证据基础：评估所提出的遗传工具变量的有效性和强度。
DOI：
10.1093/ije/dyt023
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发表时间：
2013
影响因子：
7.7
通讯作者：
Glymour,MMaria
中科院分区：
文献类型：
--
作者：
TchetgenTchetgen,EricJ;Walter,Stefan;Glymour,MMaria
孟德尔随机化（MR）研究（使用遗传多态性作为工具变量（IV）进行分析）的普及程度显着增长，反映了MR解决的因果推理问题的重要性和该方法的潜在力量。[1]虽然IV分析是一种成熟的计量经济学工具，但将遗传信息用作IV在健康研究中的应用提出了新的挑战和机遇。诸如Au Yeung等人的论文，为特定表型-结果关联提供拟议的遗传IV特征的证据，2是重要的
The remarkable growth in the popularity of mendelian randomization (MR) studies—analyses using genetic polymorphisms as instrumental variables (IVs)—reflects both the importance of the causal inference problems addressed by MR and the potential power of the approach. 1 Although IV analysis is a well-established econometric tool, applications in health research using genetic information as IVs present novel challenges and opportunities. Papers such as that of Au Yeung et al., providing evidence on the characteristics of a proposed genetic IV for a specific phenotype-outcome association, 2 are important
影响因子：
5
作者：
Glymour, M. Maria;Tchetgen, Eric J. Tchetgen;Robins, James M.
通讯作者：
Robins, James M.