Production of N-acyl-L-homoserine lactones by P-aeruginosa isolates from chronic lung infections associated with cystic fibrosis
Production of N-acyl-L-homoserine lactones by P-aeruginosa isolates from chronic lung infections associated with cystic fibrosis
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DOI：
10.1016/s0378-1097(00)00059-8
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发表时间：
2000-03-15
影响因子：
2.1
通讯作者：
Eberl, L
中科院分区：
文献类型：
--
作者：
Geisenberger, O;Givskov, M;Eberl, L
采用薄层色谱法分析了从囊性纤维化慢性感染患者中分离的铜绿假单胞菌产生的N-酰基-L-高丝氨酸内酯（AHLs）。结果表明，在慢性定植期间，来自监测长达11年的患者的分离株合成的分子的数量和类型不会发生显着变化。然而：在与产生AHL的洋葱伯克霍尔德氏菌菌株共感染的患者的情况下，观察到由共存的铜绿假单胞菌分离株产生的AHL的量显著减少。(C)2000由Elsevier Science B. V.出版，保留所有权利。
The N-acyl-L-homoserine lactones (AHLs) produced by sequential Pseudomonas aeruginosa isolates from chronically infected patients with cystic fibrosis a ere analyzed by thin-layer chromatography. It is demonstrated that both the amounts and the types of molecules synthesized by isolates from patients who were monitored over periods of up to 11 years do not change significantly during chronic colonization. However: in the case of a patient who became co-infected with an AHL-producing Burkholderia cepacia strain a dramatic reduction in the amounts of AHLs produced by the co-residing P. aeruginosa isolates was observed. (C) 2000 Published by Elsevier Science B.V. All rights reserved.