Placental corticotropin-releasing hormone: Function and regulation
Placental corticotropin-releasing hormone: Function and regulation
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DOI：
10.1016/s0002-9378(99)70708-8
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发表时间：
1999-01-01
影响因子：
9.8
通讯作者：
Karalis, KP
中科院分区：
文献类型：
--
作者：
Majzoub, JA;Karalis, KP
促肾上腺皮质激素释放激素是哺乳动物胎盘表达的一种神经肽，仅在灵长类动物中表达。其表达在妊娠的最后6至8周期间增加多达100倍，并且矛盾地受到糖皮质激素的刺激。越来越多的证据表明，胎盘促肾上腺皮质激素释放激素可能已经在灵长类动物中进化，以刺激胎儿促肾上腺皮质激素释放和肾上腺类固醇生成，从而满足合成脱氢表雄酮的高需求，脱氢表雄酮是胎盘雌二醇的主要来源。胎盘促肾上腺皮质激素释放激素对胎儿皮质醇和脱氢表雄酮的伴随刺激将糖皮质激素对胎儿器官成熟的作用与分娩时间相结合，对出生后存活有明显益处。
Corticotropin-releasing hormone is a neuropeptide placentally expressed among mammals only in primates. Its expression increases as much as 100 times during the last 6 to 8 weeks of pregnancy and is paradoxically stimulated by glucocorticoids. Increasing evidence suggests that placental corticotropin-releasing hormone may have evolved in primates to stimulate fetal adrenocorticotropin release and adrenal steroidogenesis, thus satisfying the high demand for synthesis of dehydroepiandrosterone, the predominant source of placental estradiol. Concomitant stimulation by placental corticotropin-releasing hormone of fetal cortisol and dehydroepiandrosterone would couple the glucocorticoid effects on fetal organ maturation with the timing of parturition, an obvious benefit in postnatal survival.